Effects of Resistance Training in Multiple Sclerosis: a Randomized Tri
Effects of Resistance Training in Multiple Sclerosis: a Randomized Trial. ACTIVE (Physical Activity and Its Impact on Patients With Multiple Sclerosis.)
What it found
A paper reports the results; we have not read it yet. See Papers below.
What was tested
Treatment tested
- Resistance training
Compared with
- Low aerobic training
What it measured
Main measures
Comparison of plasma light chain neurofilaments (Nfl) level
10 Weeks
Blood or spinal fluid markersPhysical function
Other measures (1)
Comparison of plasma Glial fibrillary acidic protein (GFAP) level
10 weeks
Blood or spinal fluid markersPhysical function
Who could take part
MS (type not specified) · 18 and over
Show the full criteria
Inclusion criteria
1. - Diagnosis of multiple sclerosis according to the 2017 Mc Donald criteria (Thompson A et al). 2. - Age > 18 years - up to no age limit 3. - Disability assessed by the EDSS (Expanded disability status scale) with a score less than or equal to 4. 4. - Clinical stability. Not having had an outbreak of the disease in the last 6 months. 5. - No changes in the disease-modifying treatment in the last 6 months or no treatment. 6. - Radiological stability. Patients with last MRI (magnetic resonance imaging) performed without inflammatory activity (absence of new lesions on T2 sequences or lesions that enhance with gadolinium). 7. - They must sign the informed consent
Exclusion criteria
1. - Patients with a high level of physical activity according to the International Physical Activity Questionnaire(IPAQ) or latest WHO (World Health Organization) recommendations on physical activity 2. - Pregnant or breastfeeding patients. 3. - Concomitant pathologies that limit the performance of physical exercise
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
This is a longitudinal study to examine the effects of a short-term training program on neurofilamet and GFAP plasma levels. Participants will be divided in two groups: control group (moderate aerobic training) and active group (resistance training). The change in biomarkers will be analyzed pre and post intervention in both groups. Differences between groups will be also evaluated by investigators.
Papers
Loading reviews and guidelines…
History
Started
Jan 2024
Main results due
Dec 2024
Finished
Jan 2025