Vascular Mechanisms, Functional Outcomes, & Exercise Among Persons Wit
Targeting Vascular Mechanisms of Functional Outcomes Via Home-based Exercise Training Among Persons With Multiple Sclerosis Who Have Hypertension
What it found
No result yet.
What was tested
Treatment tested
- Home-based aerobic training
What it measured
Main measures
Information processing speed
Baseline, pre-intervention/BICAMS; Within 5 days after completion of the training intervention/BICAMS
Thinking and memoryTimed 25-Foot Walk
Baseline, pre-intervention/25-Foot Walk; Within 5 days after completion of training intervention/ 25-Foot Walk
Disability progressionWalking and mobility
Other measures (4)
Blood pressure
Baseline, pre-intervention/oscillometry, applanation tonometry; Within 5 days after completion of training intervention/oscillometry, applanation tonometry
Flow-mediated dilation
Baseline, pre-intervention/ultrasonography; Within 5 days after completion of training intervention/ultrasonography
Forearm blood flow
Baseline, pre-intervention/ strain-gauge plethysmography; Within 5 days after completion of training intervention/strain-gauge plethysmography
Cardiorespiratory fitness
Baseline, pre-intervention/indirect calorimetry; Within 5 days after completion of training intervention/indirect calorimetry
Physical function
Who could take part
MS (type not specified) · 18 and over
Show the full criteria
Inclusion criteria
* Persons with confirmed multiple sclerosis diagnosis with Expanded Disability Status Scale scores of 4-6.5, characteristic of 2nd stage of multiple sclerosis; * Hypertension defined as elevated, or Stage 1 or 2, as per the 2017 American Heart Association guidelines (brachial systolic blood pressure > 120 mmHg or brachial diastolic blood pressure > 80 mmHg) * Persons who are physically inactive (less than 60 min/wk of physical activity); * Persons with body mass index \< 40 kg/m2; * Persons who are not confined to a wheel chair; * Multiple sclerosis relapse in the past 30 days; * People with stable pharmacotherapy.
Exclusion criteria
* People with additional cardiovascular comorbidities; * People with type 1 diabetes mellitus; * Physician disapproval to participating in the study; * Space constraints to fit a cycle ergometer at the home of prospective participants.
As registered. Criteria can change, so ask the trial team or your neurologist.
Contact details on the registryAbout this trial
In the sponsor's words
The goal of this study is to determine if 12 weeks of cycling exercise training at home will improve three parameters: 1) blood pressure, 2) cognition, and 3) walking ability among persons with multiple sclerosis who have high blood pressure, when compared to a group that engages in a 12-week home-based stretching program. The main questions this study aims to answer are: 1. Can home-based cycling exercise training improve blood pressure by increasing blood vessel dilation in people with multiple sclerosis? 2. Can cycling exercise training improve cognition and walking mobility in people with multiple sclerosis by improving blood pressure? The investigators will compare home-based cycling training to stretching to see if cycling training improves cognition, walking mobility, blood pressure, and fitness in people with multiple sclerosis. Participation in this study will take 13-14 weeks, with participants being randomized (like flipping a coin, a 50-50 chance of being in either group) to the home-based cycling training or the stretching group. All participants will be asked to * Visit the laboratory two times, one before the beginning of the intervention (home-base training and stretching group) and one at the end of the intervention. * During visits, participants will complete tests related to cognition, walking mobility, blood pressure and fitness.
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History
Started
Apr 2025
Main results due
Aug 2027
Finished
Aug 2027