Effect of Functional Inspiratory Muscle Training in Patients with Mult
Investigation of the Effects of Functional Inspiratory Muscle Training on Respiratory Muscle Strength, Functional Exercise Capacity and Cognitive Function in Patients with Multiple Sclerosis
What it found
No result yet.
What was tested
Treatment tested
- Functional Inspiratory Muscle Training
- Basic Inspiratory Muscle Training
What it measured
Main measures
Inspiratory Respiratory Muscle Strength
8 weeks
Physical functionExpiratory Respiratory Muscle Strength
8 weeks
Physical functionNerve conduction testsRespiratory Function (FEV₁)
8 weeks
Respiratory Function (FVC)
8 weeks
Respiratory Function (FEV₁/FVC)
8 weeks
Respiratory Function (PEF)
8 weeks
Respiratory Function (FEF%25-75)
8 weeks
Respiratory Function (VC)
8 weeks
Paced Auditory Serial Addition Test (PASAT)
8 weeks
Thinking and memorySymbol Digit Modalities Test (SDMT)
8 weeks
Thinking and memoryStroop Test
8 weeks
Thinking and memoryWalking
8 weeks
Walking and mobilityBalance
8 weeks
Walking and mobilityFunctional Exercise Capacity
8 weeks
FatigueWalking and mobilityPhysical functionPhysical Activity
8 weeks
Walking and mobilityPhysical functionQuality of Life
8 weeks
Bladder, bowel and sexual functionQuality of life (reported by participants)Core Muscles (Pelvic Bridge Test)
8 weeks
Core Muscles (Modified Plank Test)
8 weeks
Who could take part
Relapsing MS · 18 to 65 · EDSS 1 to 5
Show the full criteria
Inclusion criteria
* Diagnosed with Relapsing Remitting Type Multiple Sclerosis (RRMS), * EDSS (Expanded Disability Status Scale in MS: EDSS) score ranging from 1-5, * Able to communicate (speak, understand, read and understand Turkish), * Individuals who have not had an attack in the last three months, * Individuals who have not received respiratory-based rehabilitation in the last six months will be included in the study.
Exclusion criteria
* Those with neurological diseases other than MS, * Those who have functional exercise restrictions, * Those with chronic cardiac or pulmonary diseases such as chronic obstructive pulmonary disease (COPD), asthma, interstitial lung disease and heart failure that may affect respiratory muscle strength and respiratory functions, * Individuals who have had pneumonia due to viral or bacterial infection in the last six months or COVID-19 positive individuals proven by PCR-RT, * Those with orthopedic problems, persistent neck and back pain and/or radiculopathy that prevent them from participating in the study, * Those with diagnosed psychiatric disorders, * Those who use tobacco and tobacco products, * Participants with cooperation problems that may prevent evaluations and treatment will not be included in the study.
As registered. Criteria can change, so ask the trial team or your neurologist.
Contact details on the registryAbout this trial
In the sponsor's words
This study aims to investigate the effects of functional inspiratory muscle training, basic inspiratory muscle training and physical activity in addition to respiratory exercises on respiratory muscle strength, respiratory function, cognition, walking, balance, functional exercise capacity, physical activity, quality of life and core muscles in volunteer Multiple Sclerosis (MS) patients. This study is planned as a prospective, randomized and experimental study.
Papers
Background
Tong TK, Wu S, Nie J. Sport-specific endurance plank test for evaluation of global core muscle function. Phys Ther Sport. 2014 Feb;15(1):58-63. doi: 10.1016/j.ptsp.2013.03.003. Epub 2013 Jul 11.Background
Simeoni M, Auquier P, Fernandez O, Flachenecker P, Stecchi S, Constantinescu C, Idiman E, Boyko A, Beiske A, Vollmer T, Triantafyllou N, O'Connor P, Barak Y, Biermann L, Cristiano E, Atweh S, Patrick D, Robitail S, Ammoury N, Beresniak A, Pelletier J; MusiQol study group. Validation of the Multiple Sclerosis International Quality of Life questionnaire. Mult Scler. 2008 Mar;14(2):219-30. doi: 10.11Background
Shubert TE, Schrodt LA, Mercer VS, Busby-Whitehead J, Giuliani CA. Are scores on balance screening tests associated with mobility in older adults? J Geriatr Phys Ther. 2006;29(1):35-9.Background
Saglam M, Arikan H, Savci S, Inal-Ince D, Bosnak-Guclu M, Karabulut E, Tokgozoglu L. International physical activity questionnaire: reliability and validity of the Turkish version. Percept Mot Skills. 2010 Aug;111(1):278-84. doi: 10.2466/06.08.PMS.111.4.278-284.Background
Pellegrino R, Viegi G, Brusasco V, Crapo RO, Burgos F, Casaburi R, Coates A, van der Grinten CP, Gustafsson P, Hankinson J, Jensen R, Johnson DC, MacIntyre N, McKay R, Miller MR, Navajas D, Pedersen OF, Wanger J. Interpretative strategies for lung function tests. Eur Respir J. 2005 Nov;26(5):948-68. doi: 10.1183/09031936.05.00035205. No abstract available.Background
Neder JA, Andreoni S, Lerario MC, Nery LE. Reference values for lung function tests. II. Maximal respiratory pressures and voluntary ventilation. Braz J Med Biol Res. 1999 Jun;32(6):719-27. doi: 10.1590/s0100-879x1999000600007.Background
Miller MR, Hankinson J, Brusasco V, Burgos F, Casaburi R, Coates A, Crapo R, Enright P, van der Grinten CP, Gustafsson P, Jensen R, Johnson DC, MacIntyre N, McKay R, Navajas D, Pedersen OF, Pellegrino R, Viegi G, Wanger J; ATS/ERS Task Force. Standardisation of spirometry. Eur Respir J. 2005 Aug;26(2):319-38. doi: 10.1183/09031936.05.00034805. No abstract available.Background
Lin MR, Hwang HF, Hu MH, Wu HD, Wang YW, Huang FC. Psychometric comparisons of the timed up and go, one-leg stand, functional reach, and Tinetti balance measures in community-dwelling older people. J Am Geriatr Soc. 2004 Aug;52(8):1343-8. doi: 10.1111/j.1532-5415.2004.52366.x.Background
ATS Committee on Proficiency Standards for Clinical Pulmonary Function Laboratories. ATS statement: guidelines for the six-minute walk test. Am J Respir Crit Care Med. 2002 Jul 1;166(1):111-7. doi: 10.1164/ajrccm.166.1.at1102. No abstract available.Background
Akuthota V, Ferreiro A, Moore T, Fredericson M. Core stability exercise principles. Curr Sports Med Rep. 2008 Feb;7(1):39-44. doi: 10.1097/01.CSMR.0000308663.13278.69.
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History
Started
Nov 2024
Main results due
Oct 2025
Finished
Dec 2025