Effects of Upper Extremity-Focused Neuromuscular Training in People Wi

Effects of Upper Extremity-Focused Neuromuscular Exercise Training on Physical and Cognitive Functions in People With Multiple Sclerosis (NExTUp)

Not yet recruitingNot a drug-phase studyRelapsing MSNCT06712342

What it found

Still running

No result yet.

What was tested

Treatment tested

  • Neuromuscular Exercise Training

Compared with

  • Conventional Exercise Training

What it measured

Main measures

  • Nine Hole Peg Test

    At the beginning, at the end of 8 weeks and 12 weeks

    Arm and hand function

  • Minnesota Manual Dexterity Test

    At the beginning, at the end of 8 weeks and 12 weeks

    Arm and hand function

  • Manual Ability Measure-36

    At the beginning, at the end of 8 weeks and 12 weeks

    Arm and hand function

  • Timed 25-Foot Walk

    At the beginning, at the end of 8 weeks and 12 weeks

    Disability progressionWalking and mobility

  • Symbol Digit Modalities Test

    At the beginning, at the end of 8 weeks and 12 weeks

    Thinking and memory

  • Hand Dynamometer

    At the beginning, at the end of 8 weeks and 12 weeks

    Arm and hand functionPhysical function

Other measures (7)

  • Hand Held Dynamometer

    At the beginning, at the end of 8 weeks and 12 weeks

    Physical function

  • Biodex Balance System

    At the beginning, at the end of 8 weeks and 12 weeks

    Walking and mobility

  • Laser-pointer Assisted Angle Reproduction Test

    At the beginning, at the end of 8 weeks and 12 weeks

  • Finger Tapping Test

    At the beginning, at the end of 8 weeks and 12 weeks

    Arm and hand function

  • Fatigue Severity Scale

    At the beginning, at the end of 8 weeks and 12 weeks

    Fatigue

  • Plank

    At the beginning, at the end of 8 weeks and 12 weeks

    Physical function

  • Curl-up

    At the beginning, at the end of 8 weeks and 12 weeks

    Physical function

Who could take part

Relapsing MS · 18 to 64

Show the full criteria

Inclusion criteria

* Definite MS according to McDonald criteria, * 18-64 years * RRMS, * EDSS \< 4, * Minimal or moderate upper extremity involvement

Exclusion criteria

* Having an attack in the last three months, * Mini Mental Test \<24 or visual deficit, * Other medical conditions accompanying MS (cardiac, orthopedic or rheumatic, etc.), * Being pregnant or breastfeeding, * Doing regular exercise - receiving physiotherapy, * Having spasticity of 2 or more in the upper extremity

As registered. Criteria can change, so ask the trial team or your neurologist.

Contact details on the registry

About this trial

In the sponsor's words

The effectiveness of upper extremity focused neuromuscular exercise training in early stage people with MS will be investigated. People with MS enrolled in the study will be randomly assigned to three groups: Neuromuscular Exercise Group (NEG), Conventional Exercise Group (CEG), and Control Group (CG). All three groups will be assessed with primary and secondary outcome measures at baseline, week 8, and week 12. NEG, CEG, and CG will be initially assessed for upper extremity function, cognitive function, lower extremity function, grip strength, proximal muscle strength, sensation, coordination, fatigue, postural sway, and core muscle strength and endurance. Then, NEG will receive clinically supervised upper extremity focused neuromuscular exercise training with a minimum of 60 minutes of session time, 2 days a week for 8 weeks. This exercise training includes steps for postural control, weight transfer, proximal and distal muscle strengthening, proprioception, coordination and reaction speed. Similarly, CEG will receive clinically supervised traditional upper extremity exercise training, twice a week for 8 weeks, with a minimum of 60 minutes of session time. This exercise training includes strengthening with the band and manuel dexterity exercises. In both groups, stretching and mobility exercises will be added to the warm-up and cool-down exercises before and after the program. During this process, CG will be on the waiting list. At the end of 8 weeks, all three groups will be re-evaluated. After the exercise training, follow-up will be done and evaluations will be repeated in the 12th week. This study will provide evidence on the effects of upper extremity-focused neuromuscular exercise training on physical and cognitive functions in early-stage people with MS compared to traditional treatment approaches.

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History

    1. Started

      Nov 2024

    2. Main results due

      Nov 2025

    3. Finished

      Dec 2025

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