Comparing the Acute Effects of Different Exercise Approaches in Patien

Comparing the Acute Effects and Cortical Hemodynamic Response of Different Exercise Approaches in Patients With Multiple Sclerosis: fNIRS Study

CompletedNot a drug-phase studyRelapsing MSNCT06721416

We could not find results for this trial

What it found

No results found

We found no results in the registry or in papers.

This trial finished 15 months ago. We found no results in the registry or in any paper that cites it.

What was tested

Treatment tested

  • Traditional Aerobic Exercise
  • VR Based Aerobic Exercise
  • Conventional Exercise

What it measured

Main measures

  • Energy Spent

    For 30 minutes during the entire exercise

    Physical function

  • Cortical Activity

    During preintervention cognitive tasks, for 30 minutes during the entire exercise, during postintervention cognitive tasks

    Thinking and memoryPhysical functionNerve conduction tests

  • Body Temperature

    immediately before the exercise, immediately after the exercise

    Physical function

  • Electrodermal Activity

    During preintervention cognitive tasks, for 30 minutes during the entire exercise, during postintervention cognitive tasks

  • Cognitive Function

    Immediately before the exercise, immediately after the exercise

    Thinking and memoryFatiguePhysical function

  • Cognitive Function

    Immediately after the exercise

    Thinking and memoryPhysical function

  • Physical Fatigue

    Immediately after the exercise

    FatiguePhysical function

  • Satisfaction Level satisfaction level Satisfaction Level

    Immediately after the exercise

    Quality of life (reported by participants)

  • Late-term fatigue

    24 hours later after the exercise

    FatiguePhysical functionPain

Who could take part

Relapsing MS · 18 to 55

Show the full criteria

Inclusion criteria

* Diagnosed as Relapsing Remitting MS by neurologist according to the McDonald Criteria. * 18-55 years old. * EDSS score \< 4.5 * Mini mental examination test score ≥ 24 * No MS attack in the last 6 months. * No visual or vestibular deficits. * Signed the written consent form.

Exclusion criteria

* Having previous full immersive VR experience. * Having an additional neurological disease. * Spasticity in any muscle of the upper extremity > 3, according to MAS. * Continuing the active physical therapy and rehabilitation program.

As registered. Criteria can change, so ask the trial team or your neurologist.

About this trial

In the sponsor's words

Multiple Sclerosis (MS) is the second most common neurological disorder in young adults after trauma. Treatments developed today can slow progression and reduce symptoms. Exercise therapy is a useful rehabilitation practice in MS to manage symptoms, restore function, optimize quality of life, ensure well-being and increase participation in daily life activities. In this study, it is planned to investigate the acute effects of conservative and virtual reality (VR)-based aerobic exercise applications and standard exercises that frequently form the rehabilitation programs of individuals with MS in clinics. For this purpose, patients with MS who met the inclusion criteria were given two-week intervals; Conservative aerobic exercise, virtual reality-based aerobic exercise and standard exercise practices will be performed. With the data obtained from this study, it is aimed to investigate the safety of aerobic exercises performed using VR tools that can be used in telerehabilitation applications, which are thought to have a very important place in MS rehabilitation in the future, in terms of acute body temperature increase, cognitive and physical fatigue caused by conservative methods and fNIRS cortical effects of VR-based aerobic exercise applications. It will be possible to prove it with objective methods such as.

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History

    1. Started

      Dec 2024

    2. Main results due

      Jul 2025

    3. Finished

      Aug 2025

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