Transcranial Electrical Stimulation in Multiple Sclerosis
The Effect of Transcranial Direct Current Stimulation on Cerebral Blood Flow in Patients With Multiple Sclerosis
What it found
No result yet.
What was tested
Treatment tested
- transcranial Direct Current Stimulation
What it measured
Main measures
Cerebral blood flow (CBF)
Visit 1 (baseline), visit 2 (+-1 week after visit 1), visit 3 (2 years after visit 1)
Other measures (8)
Symbol Digit Modalities Test (SDMT)
Baseline and after 2 years
Thinking and memoryCalifornia Verbal Learning Test (CVLT-II)
Baseline and after 2 years
Thinking and memoryControlled Oral Word Association Test (COWAT)
Baseline and after 2 years
Brief visuospatial Memory Test (BVMT-R)
Baseline and after 2 years
Thinking and memoryFatigue Scale for Motor and Cognitive Function (FSMC)
Baseline and after 2 years
Thinking and memoryFatigueBeck's depression inventory (BDI)
Baseline and after 2 years
Mood and sleepMRI T1 scan
Baseline and after 2 years
MRI lesionsMRI T2 FLAIR scan
Baseline and after 2 years
MRI lesions
Who could take part
MS (type not specified) · 18 and over
Show the full criteria
Inclusion criteria
Inclusion criteria - MS patient * EDSS ≥ 2 and EDSS ≤ 6.5 * Age ≥ 18 Exclusion criteria - MS patient * EDSS > 6.5 * Incompatibility with MRI * Relapse within three months before the study and its use of corticosteroids * Disabling concomitant neuropsychiatric diseases * Chance of pregnancy, breastfeeding * Contraindications to tDCS Inclusion criteria - Healthy Volunteer • Age ≥ 18 Exclusion criteria - Healthy Volunteer * Incompatibility with MRI * Disabling concomitant neuropsychiatric diseases * Chance of pregnancy, breastfeeding * Contraindications to tDCS
Exclusion criteria
Not separately supplied in the registry.
As registered. Criteria can change, so ask the trial team or your neurologist.
Contact details on the registryAbout this trial
In the sponsor's words
First the investigators will examine if the blood flow in the brain is different in patients with Multiple Sclerosis compared to healthy volunteers. HOW? - The blood flow of the subjects is imaged by use of a special MRI-technique. Secondly, the investigators will examine if the blood flow can determine disease progression. HOW? - Multiple Sclerosis patients are asked for a follow-up visit after two years. The main goal is to understand the effect of transcranial Direct Current Stimulation (tDCS) on the cerebral blood flow. * Does tDCS result in a different blood flow, in which brain regions? * Is there a difference between healthy volunteers and Multiple Sclerosis patients? HOW? - Participants get two session of tDCS. Before, during and after stimulation MRI scans are performed.
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History
Started
Jun 2025
Main results due
Jan 2029
Finished
Jan 2029