Effectiveness of Personalized Alternating Current Stimulation for Trea
This Study is Designed to Evaluate the Efficacy of Personalized Alternating Current Stimulation in the Treatment of Working Memory in Patients With Inflammatory Demyelination of the Central Nervous System
What it found
No result yet.
What was tested
Treatment tested
- Neuroelectrics StarStim 32
Placebo
- Neuroelectrics StarStim 32
What it measured
Main measures
Working Memory Training-Related Scores
An hour before and after interventions
Thinking and memoryFeasibilitySDMT (Symbol Digit Modalities Test)
An hour before and after interventions.
Thinking and memory
Other measures (4)
AVLT (Auditory Verbal Learning Test)
Before interventions
Thinking and memoryFeasibilityDigit Span Test
An hour before interventions
Thinking and memoryBVMTR (Brief Visual Memory Test-Revised)
An hour before and after interventions.
Thinking and memorySTROOP (Stroop Color and Word Test)
An hour before and after interventions.
Thinking and memory
Who could take part
MS (type not specified) · 18 to 65
Show the full criteria
Inclusion criteria
* Patients with Neuromyelitis Optica Spectrum Disorders (NMOSD), Multiple Sclerosis (MS), and other Central Nervous System Inflammatory Demyelinating Diseases that meet diagnostic criteria; * Patients with SDMT scores \<55 or subjective cognitive decline; * Age between 18 and 65 years, gender unrestricted; * No relapse or medication changes in the past month; * EDSS (Expanded Disability Status Scale) score ≤6; * Right-handed, native Chinese speakers with sufficient educational background to understand the test instructions; -Willing to participate and have signed informed consent.-
Exclusion criteria
* Relapse record within the past month; * Medication adjustment within the past month or having undergone modified electroconvulsive therapy, transcranial magnetic stimulation, or other neuromodulation techniques; * Participating in any other clinical research within 1 month prior to enrollment or currently; * Presence of cochlear hearing aids, cardiac pacemakers, or implanted brain stimulation devices; * Skin integrity damage at electrode placement sites, or allergy to electrode gel or adhesives; * History of epilepsy, hydrocephalus, central nervous system tumors, brain injury, or intracranial infections; * Pregnant or lactating women, or those planning pregnancy in the near future; * Scoring ≥3 on item 3 (suicide item) of the HDRS-17 or concurrent severe mental illness; * Concurrent severe or unstable organic diseases; * Unable to cooperate with treatment, follow-up, or clinical, EEG, and imaging data collection due to poor patient compliance; * Other situations deemed inappropriate for study participation by the researchers.
As registered. Criteria can change, so ask the trial team or your neurologist.
Contact details on the registryAbout this trial
In the sponsor's words
Background: Central nervous system inflammatory demyelinating diseases often lead to significant cognitive impairment, presenting a critical challenge in patient management. Objective: To evaluate the effectiveness of individualized transcranial electrical stimulation (tES) in improving cognitive function among patients with inflammatory demyelinating disorders. Methods: This study will assess cognitive performance through standardized neuropsychological assessments before and after individualized a one-time tES intervention, measuring changes in cognitive domains including working memory, attention, executive function, and processing speed. Anticipated Results: We hypothesize that personalized transcranial electrical stimulation will demonstrate significant improvements in cognitive performance, potentially offering a non-invasive therapeutic approach for managing cognitive decline in central nervous system inflammatory demyelinating diseases. Significance: This research may provide novel insights into neuromodulation strategies for cognitive rehabilitation in patients with complex neurological conditions.
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History
Started
Dec 2024
Main results due
Jul 2027
Finished
Oct 2027