tdCS Combined With Treadmill Training in Patients With Multiple Sclero
Transcranial Direct Current Stimulation Combined With Treadmill Training With Partial Body Weight Support in Patients With Multiple Sclerosis
What it found
No result yet.
What was tested
Treatment tested
- tDCS
Placebo
- shamtDCS
What it measured
Main measures
TUG
Pre intervention, at the end of 10th session, and follow-up at 4 weeks
Walking and mobilityTimed 25-Foot Walk
Pre intervention, at the end of 10th session, and follow-up at 4 weeks
Disability progressionWalking and mobility
Other measures (2)
MSWS-12
Pre intervention, at the end of 10th session, and follow-up at 4 weeks
Walking and mobilityQuality of life (reported by participants)FSS
Pre intervention, at the end of 10th session, and follow-up at 4 weeks
Fatigue
Who could take part
MS (type not specified) · 18 and over · EDSS 1 to 6
Show the full criteria
Inclusion criteria
* Ability to understand and follow instructions. * Diagnosis of Multiple Sclerosis according to McDonald criteria. * Expanded Disability Status Scale (EDSS) between 1 and 6. * Stable condition in the last three months.
Exclusion criteria
* Peripheral neurological injury of lower limbs. * Metal objects in the head. * Uncontrolled epilepsy. * Diagnosis of psychiatric disorder. * Fractures or fissures in the skull. * Presence of any implanted electronic device (pacemaker, baclofen pump). * Presence of ulcers in the harness attachment area. * Osteoporotic fractures in the last 2 years. * Height > 190 cm. * Weight > 120 kg.
As registered. Criteria can change, so ask the trial team or your neurologist.
Contact details on the registryAbout this trial
In the sponsor's words
This clinical trial aims to evaluate the therapeutic effectiveness of transcranial direct current stimulation (tDCS), a non-invasive technique that modulates cortical excitability, in combination with gait training in patients with multiple sclerosis (MS). The study focuses on improving balance and walking ability, which are commonly impaired in this population. A randomized, triple-blind, controlled design will be used, comparing an active tDCS group with a sham stimulation group, both receiving the same gait training protocol. Outcomes will include functional and clinical measures related to mobility, balance, and fatigue. The project builds on previous meta-analytical evidence suggesting positive effects of tDCS in MS and aims to confirm these findings using an optimized stimulation protocol.
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History
Started
May 2025
Main results due
Aug 2025
Finished
Dec 2025