Cerebellar High-Frequency rTMS in Balance of Multiple Sclerosis Patien
Effect of Cerebellar High-Frequency rTMS in Improving Balance Performance in Multiple Sclerosis Patients
We could not find results for this trial
What it found
We found no results in the registry or in papers.
This trial finished 22 months ago. We found no results in the registry or in any paper that cites it.
What was tested
Treatment tested
- cerebellar rTMS
What it measured
Main measures
Static posturography
3 years
Walking and mobilityInternational Cooperative Ataxia Rating Scale (ICARS)
3 years
Physical functionExpanded Disability Status Scale (EDSS)
3 years
Disability progression
Other measures (1)
10-Meter Walk Test (10MWT)
3 years
Walking and mobility
Who could take part
MS (type not specified) · 18 to 60 · EDSS 2.5 to 5
Show the full criteria
Inclusion criteria
* Patient age ≥18 years. * Patients with MS, established by clinical, laboratory, MRI criteria and matched Mc Donald's criteria, McDonald et al, 2006. * Expanded Disability Status Scale (EDSS) scores between 2.5-5 * Only patients in "remitting" phase were included. * Informed consent.
Exclusion criteria
* Factors that prevent patient cooperation understanding that impede proper study participation. * Disabling medical history as severe or recent heart disease and or severe head trauma. * Cognitive impairment: \<24 points by mini-mental scale. (Folstein MF et al., 1975). * Diabetic patients. * Patients with any other comorbidity that can affect balance, e.g, other neurological diseases that can affect posterior column function. * Contraindications for rTMS: 1. History of epilepsy. 2. Metal (implants) in skull/scalp/head or fragments from welding or metalwork. 3. Implanted device (as spinal cord stimulator, cardiac pacemaker, and cochlear implants). 4. Pregnancy.
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
Background: Multiple Sclerosis (MS) is a chronic autoimmune disease affecting the central nervous system (CNS), leading to progressive motor dysfunction and balance deficits. Objective: To investigate the impact of cerebellar rTMS in improving postural control, balance performance and functional ambulation in individuals with MS. Forty patients were randomly assigned to receive repetitive transcranial magnetic stimulation (rTMS) over the cerebellum to improve motor function and balance in 40 MS patients. Outcome measures, including the Expanded Disability Status Scale (EDSS), static posturography (COP measures), the International Cooperative Ataxia Rating Scale (ICARS), and the 10-Meter Walk Test (10MWT), were assessed before and after intervention.
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History
Started
Feb 2023
Main results due
Dec 2024
Finished
Mar 2025