Motor Learning in Health and Movement Disorders: Role of Physical Acti
Motor Planning, Execution, and Modulation in Healthy Individuals and Patients With Movement Disorders or Neuromuscular Diseases Using Traditional Physical Activity or Advanced Devices to Enhance Motor Learning and Sensorimotor Processing
What it found
No result yet.
What was tested
Treatment tested
- CAREN
Compared with
- Control group
What it measured
Main measures
Amplitude of Motor-Related Event-Related Potentials (ERPs) During Gesture Execution Assessed by EEG.
Baseline (T0), post-intervention (T1, 12 weeks after baseline), and follow-up (T2, 3 months post-intervention).
Nerve conduction tests
Other measures (2)
Respiratory Exchange Ratio (RER) During Submaximal Exercis
Baseline (T0), post-intervention (T1, 12 weeks after baseline), and follow-up (T2, 3 months post-intervention).
Physical functionChange in Global Cognitive Function as Measured by MoCA Total Score
Baseline (T0), post-intervention (T1, 12 weeks after baseline), and follow-up (T2, 3 months post-intervention).
Thinking and memory
Who could take part
MS (type not specified) · 18 to 70
Show the full criteria
Inclusion criteria
* Montreal Cognitive Assessment (MoCA) score (adjusted for age and education) equal to or greater than 20.
Exclusion criteria
* Severe medical and psychiatric disorders potentially affecting the training
As registered. Criteria can change, so ask the trial team or your neurologist.
Contact details on the registryAbout this trial
In the sponsor's words
The goal of this clinical trial is to investigate motor responses in healthy subjects and patients with movement disorders, brain and spinal cord injury, neuromuscular diseases, or cardiovascular diseases. This study aims to evaluate the effectiveness of traditional physical activities combined with innovative interventions such as cryotherapy, ultrasound therapy, laser therapy, transcranial magnetic stimulation (TMS), and transcranial direct current stimulation (tDCS). It will also assess the impact of proprioceptive stimuli provided by either the immersive virtual reality (CAREN), or visuo-cognitive-motor enhancement (S.V.T.A.), and music therapy. The main questions it aims to answer are: How do these interventions affect motor activities and their functional recovery? What are the temporal and spatial changes in activation sequences related to motor learning and maintenance? When there is a comparison group: Researchers will compare outcomes between different intervention arms (e.g., physical activity with advanced devices vs. traditional methods) to find out if the advanced interventions result in better motor control and functional recovery. Participants will: * Undergo various rehabilitation protocols including physical activity and advanced interventions. * Be assessed using different tool, such as fMRI, dtMRI, and NIRS to study in vivo neuroimaging and assess changes in brain function and connectivity.
Papers
Results
De Pasquale P, Bonanno M, Lombardo Facciale A, Maggio MG, Thaut MH, Hurt C, Quartarone A, Impellizzeri F, Calabro RS. Can neurologic music therapy make the difference when using immersive virtual reality in Parkinson disease motor training? Promising findings from a secondary analysis. Front Rehabil Sci. 2026 Feb 26;7:1707528. doi: 10.3389/fresc.2026.1707528. eCollection 2026.Background
Bonanno M, De Pasquale P, De Marchis C, Lombardo Facciale A, Paladina G, Fonti B, Quartarone A, Calabro RS. Might patients with cerebellar ataxia benefit from the Computer Assisted Rehabilitation ENvironment (CAREN)? A pilot study focusing on gait and balance. Front Bioeng Biotechnol. 2024 Jun 24;12:1385280. doi: 10.3389/fbioe.2024.1385280. eCollection 2024.
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History
- Status changed from Running, not recruiting to Recruiting
- Primary completion date changed from 5 May 2026 to 6 December 2028
- Completion date changed from 31 December 2026 to 31 December 2028
Started
May 2024
Main results due
Dec 2028
Finished
Dec 2028