Motor Planning, Execution, and Modulation in Healthy Individuals and Patients With Movement Disorders or Neuromuscular Diseases Using Traditional Physical Activity or Advanced Devices to Enhance Motor Learning and Sensorimotor Processing

RecruitingNot a drug-phase studyMS (type not specified)NCT07066137

What it found

Still running

No result yet.

What was tested

Treatment tested

  • CAREN

Compared with

  • Control group

What it measured

Main measures

  • Amplitude of Motor-Related Event-Related Potentials (ERPs) During Gesture Execution Assessed by EEG.

    Baseline (T0), post-intervention (T1, 12 weeks after baseline), and follow-up (T2, 3 months post-intervention).

    Nerve conduction tests

Other measures (2)

  • Respiratory Exchange Ratio (RER) During Submaximal Exercis

    Baseline (T0), post-intervention (T1, 12 weeks after baseline), and follow-up (T2, 3 months post-intervention).

    Physical function
  • Change in Global Cognitive Function as Measured by MoCA Total Score

    Baseline (T0), post-intervention (T1, 12 weeks after baseline), and follow-up (T2, 3 months post-intervention).

    Thinking and memory

Who could take part

MS (type not specified) · 18 to 70

Show the full criteria

Inclusion criteria

* Montreal Cognitive Assessment (MoCA) score (adjusted for age and education) equal to or greater than 20.

Exclusion criteria

* Severe medical and psychiatric disorders potentially affecting the training

As registered. Criteria can change, so ask the trial team or your neurologist.

Contact details on the registry

About this trial

In the sponsor's words

The goal of this clinical trial is to investigate motor responses in healthy subjects and patients with movement disorders, brain and spinal cord injury, neuromuscular diseases, or cardiovascular diseases. This study aims to evaluate the effectiveness of traditional physical activities combined with innovative interventions such as cryotherapy, ultrasound therapy, laser therapy, transcranial magnetic stimulation (TMS), and transcranial direct current stimulation (tDCS). It will also assess the impact of proprioceptive stimuli provided by either the immersive virtual reality (CAREN), or visuo-cognitive-motor enhancement (S.V.T.A.), and music therapy. The main questions it aims to answer are: How do these interventions affect motor activities and their functional recovery? What are the temporal and spatial changes in activation sequences related to motor learning and maintenance? When there is a comparison group: Researchers will compare outcomes between different intervention arms (e.g., physical activity with advanced devices vs. traditional methods) to find out if the advanced interventions result in better motor control and functional recovery. Participants will: * Undergo various rehabilitation protocols including physical activity and advanced interventions. * Be assessed using different tool, such as fMRI, dtMRI, and NIRS to study in vivo neuroimaging and assess changes in brain function and connectivity.

Papers

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History

  1. Status changed from Running, not recruiting to Recruiting
  2. Primary completion date changed from 5 May 2026 to 6 December 2028
  3. Completion date changed from 31 December 2026 to 31 December 2028
  1. Started

    May 2024

  2. Main results due

    Dec 2028

  3. Finished

    Dec 2028

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