Effects of tDCS and Cognitive Rehabilitation on Cognition and Neural P

The Effect of Trans-cranial Direct Current Stimulation and Cognitive Rehabilitation on Cognitive Functions and Neuronal Plasticity inPatients With Multiple Sclerosis: A Randomized Controlled Trial

CompletedNot a drug-phase studyRelapsing MSNCT07160218

We could not find results for this trial

What it found

No results found

We found no results in the registry or in papers.

This trial finished 15 months ago. We found no results in the registry or in any paper that cites it.

What was tested

Treatment tested

  • tDCS
  • Cognitive Rehabilitation

Placebo

  • Sham tDCS

What it measured

Main measures

  • Change in verbal memory performance measured by California Verbal Learning Test-II (CVLT-II)

    Baseline and immediately after 10 intervention sessions

    Thinking and memory

  • Change in attention performance measured by Integrated Visual and Auditory Continuous Performance Test (IVA-2)

    Baseline and immediately after 10 intervention sessions

    Thinking and memory

  • Change in visuospatial memory performance measured by Rey-Osterrieth Complex Figure Test

    Baseline and immediately after 10 intervention sessions

    Thinking and memory

  • Change in serum BDNF levels (ng/mL)

    Baseline and immediately after 10 intervention sessions

  • Change in white matter integrity measured by Diffusion Tensor Imaging (DTI)

    Baseline and immediately after 10 intervention sessions

    MRI lesions

  • Change in acetylcholinesterase (AChE) activity in blood (U/mL)

    Baseline and immediately after 10 intervention sessions

Who could take part

Relapsing MS · 20 to 50

Show the full criteria

Inclusion criteria

Age between 20 and 50 years. Diagnosed with relapsing-remitting multiple sclerosis (RRMS). Mild disability, defined as EDSS \< 5. Patients who attended the neurology clinic and are willing to participate.

Exclusion criteria

Presence of psychiatric disorders requiring treatment with neuroleptics. History of seizures. Left-handed individuals. Recent MS relapse requiring steroid treatment. Pregnant women. History of brain surgery or presence of intracranial clips.

As registered. Criteria can change, so ask the trial team or your neurologist.

About this trial

In the sponsor's words

The goal of this clinical trial is to evaluate whether transcranial direct current stimulation (tDCS) and cognitive rehabilitation can improve cognitive functions and neuronal plasticity in patients with multiple sclerosis (MS). The participant population consists of MS patients (both sexes, adults), who commonly experience cognitive impairment in addition to physical and psychological symptoms. The main questions it aims to answer are: Does tDCS applied over the left dorsolateral prefrontal cortex improve cognitive abilities in MS patients? Does the combination of tDCS and cognitive rehabilitation enhance neuroplasticity, as measured by DTI, BDNF levels, and acetylcholinesterase activity?

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History

    1. Started

      Jan 2024

    2. Main results due

      Aug 2025

    3. Finished

      Aug 2025

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