MS Synchronous vs Asynchronous Exercise Study

Comparison of the Effects of Synchronous and Asynchronous Exercise Programs in Patients With Multiple Sclerosis

CompletedNot a drug-phase studyRelapsing MSNCT07233902

We could not find results for this trial

What it found

No results found

We found no results in the registry or in papers.

This trial finished 13 months ago. We found no results in the registry or in any paper that cites it.

What was tested

Treatment tested

  • Combined Exercise Program (Synchronous Delivery)

Compared with

  • Combined Exercise Program (Asynchronous Delivery)

What it measured

Main measures

  • 6 Minute Walk Test

    24 weeks

    Walking and mobilityPhysical function

  • Respiratory Muscle Strength

    24 weeks

    Physical function

  • Fatigue Severity Scale

    24 weeks

    Fatigue

  • Multiple Sclerosis Quality of Life Scale

    24 weeks

    Thinking and memoryBladder, bowel and sexual functionPainQuality of life (reported by participants)

  • Five Times Sit-to-Stand Test

    24 weeks

    Walking and mobilityPhysical function

Other measures (5)

  • Beck Depression Inventory

    24 weeks

    Mood and sleep

  • Beck Anxiety Inventory

    24 weeks

    Mood and sleep

  • Montreal Cognitive Assessment

    24 weeks

    Thinking and memory

  • Berg Balance Scale

    24 weeks

    Walking and mobility

  • Dynamic Gait Index

    24 weeks

    Walking and mobility

Who could take part

Relapsing MS · 18 to 55 · EDSS 2.0 to 5.5

Show the full criteria

Inclusion criteria

* Diagnosis of Relapsing-Remitting Multiple Sclerosis (RRMS) according to the McDonald criteria. * Age between 18 and 55 years. * Expanded Disability Status Scale (EDSS) score between 2.0 and 5.5. * No relapse within the last six months. * Access to the necessary technological infrastructure (internet, camera, and microphone) to participate in the synchronous exercise program.

Exclusion criteria

* Presence of any neurological diagnosis other than MS. * Any vestibular, cardiovascular, or orthopedic condition that limits exercise participation or increases fall risk (Jallouli et al., 2022). * Mini-Mental State Examination (MMSE) score below 24. * Timed Up and Go (TUG) test result greater than 14.2 seconds, indicating elevated fall risk (Block et al., 2022). * Severe visual or auditory impairments. * Presence of a psychiatric diagnosis. * Current participation in another exercise or physiotherapy/rehabilitation program. * Pregnancy.

As registered. Criteria can change, so ask the trial team or your neurologist.

About this trial

In the sponsor's words

This randomized controlled study aims to compare the effects of synchronous and asynchronous exercise programs on individuals diagnosed with relapsing-remitting multiple sclerosis (RRMS). Participants meeting the inclusion criteria (EDSS score between 2 and 5.5, aged 18-55) were randomly assigned to either the Synchronous Exercise Group (SEG) or the Asynchronous Exercise Group (ASEG). The synchronous program was delivered via live online sessions using Google Meet and WhatsApp video calls, while the asynchronous program consisted of pre-recorded exercise videos accessible to participants. Both programs included structured exercises focusing on functional capacity, muscle strength, fatigue, independence, and quality of life. The sample size was determined using G*Power software based on previous studies in individuals with multiple sclerosis, targeting a total of 16. Statistical analyses will be conducted using SPSS 26.0. Parametric and non-parametric tests will be used depending on data distribution, with significance set at p \< 0.05. The study seeks to improve accessibility to exercise programs for MS patients and provide evidence for the efficacy of remotely delivered synchronous versus asynchronous rehabilitation models.

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History

    1. Started

      Apr 2025

    2. Main results due

      Oct 2025

    3. Finished

      Oct 2025

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