Eccentric Cycling in Multiple Sclerosis Rehabilitation

Eccentric Cycling : a New Training Modality in Multiple Sclerosis Rehabilitation

Running, not recruitingNot a drug-phase studyMS (type not specified)NCT07316764

What it found

Still running

No result yet.

What was tested

Treatment tested

  • Eccentric training

Compared with

  • Concentric training

What it measured

Main measures

  • Maximal Isometric Force

    At baseline and endline of intervention (Week 1 and 14)

  • Walking distance

    At baseline and endline of intervention (Week 1 and 14)

    Walking and mobility

  • Glial Fibrillary Acidic Protein (GFAP)

    At baseline and endline of intervention (Week 1 and 4)

    Disability progressionRelapsesBlood or spinal fluid markers

  • Neurofilament Light Chain (NfL)

    At baseline and endline of intervention (week 1 and 4)

    RelapsesBlood or spinal fluid markers

Other measures (12)

  • Handgrip strength

    At baseline and endline of intervention (Week 1 and 14)

    Arm and hand functionPhysical function

  • Spasticity

    At baseline and endline of intervention (Week 1 and 14)

    Spasticity

  • Timed up and go

    At baseline and endline of intervention (Week 1 and 14)

    Walking and mobility

  • Neurocognitive capacity

    At baseline and endline of intervention (Week 1 and 14)

    Thinking and memory

  • Berg Balance Scale

    At baseline and endline of intervention (Week 1 and 14)

    Walking and mobility

  • Five time sit to stand test

    At baseline and endline of intervention (Week 1 and 14)

  • Maximal aerobic power

    At baseline and endline of intervention (Week 1 and 14)

    Physical function

  • Maximal oxygen consumption

    At baseline and endline of intervention (Week 1 and 14)

    Physical function

  • Fatigue

    At baseline and endline of intervention (Week 1 and 14)

    Fatigue

  • Multiple Sclerosis Quality of Life-54

    At baseline and endline of intervention (Week 1 and 14)

    Quality of life (reported by participants)

Who could take part

MS (type not specified) · 18 to 75

Show the full criteria

Inclusion criteria

* Diagnosis of multiple sclerosis * Multiple sclerosis: EDSS score \< 7 * Age under 75 years * Stable disease state * Written medical clearance authorizing participation * Legal adult status * Written informed consent, with demonstrated understanding of the consent form (via a few specific questions) * Ability to mobilize independently (e.g., transfers, walking)

Exclusion criteria

* One or more contraindications to physical activity * Significant comorbidities * Active flare-up

As registered. Criteria can change, so ask the trial team or your neurologist.

About this trial

In the sponsor's words

The project aims to optimise functional rehabilitation programmes for people with multiple sclerosis. Investigators are proposing eccentric cycling as a new exercise modality for treating these patients. Based on previous results in healthy subjects, investigators will attempt to define the optimal parameters of this new modality (in terms of duration, intensity, frequency, etc.). Investigators also aim to demonstrate the effectiveness of this training (compared to conventional training) in improving muscle function, functional capacity, perception of chronic fatigue, quality of life, physical condition, and neurological and cognitive function.

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History

    1. Started

      Mar 2026

    2. Main results due

      Dec 2026

    3. Finished

      Jul 2027

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