THE EFFECTS OF AEROBİC EXERCİSE ON NEUROVASCULAR UNİT AND CLİNİCAL PRO
THE EFFECTS OF AEROBİC EXERCİSE ON NEUROVASCULAR UNİT AND CLİNİCAL PROGRESSİON MARKERS İN INDİVİDUALS WİTH MULTİPLE SCLEROSİS
We could not find results for this trial
What it found
We found no results in the registry or in papers.
This trial finished 16 months ago. We found no results in the registry or in any paper that cites it.
What was tested
Treatment tested
- aerobic exercise intervention
What it measured
Main measures
clinical progression
From enrollment to the end of treatment at 8 weeks
Disability progressionWalking and mobilityArm and hand functionPhysical function
Other measures (1)
Neurovascular unit biomarkers
From enrollment to the end of treatment at 8 weeks
Blood or spinal fluid markersPhysical function
Who could take part
MS (type not specified) · 20 to 50 · EDSS 0 to 4.0
Show the full criteria
Inclusion criteria
* Having a definite diagnosis of MS according to McDonald criteria, * Being aged between 20 and 50, * Having a Standardised Mini Mental Test (SMMT) score of ≥24, * Having an Expanded Disability Status Scale (EDSS) score between 0 and 4.0, * Having no other serious health problems that would prevent exercise, * Having had no change in medication in the last 6 months.
Exclusion criteria
* Having experienced an MS relapse within the last 6 months, * Having an orthopaedic or systemic problem that would prevent participation in the exercises, * Having another known neuromuscular disorder besides MS, * Having received immunomodulatory treatment within the last 6 months, * Having a cardiopulmonary disorder that could prevent participation in the exercise, * Being pregnant or breastfeeding. Criteria for exclusion from the study: * Failure to attend three consecutive sessions of the exercise programme * Change in ongoing pharmacological treatment or discontinuation of pharmacological treatment * Development of a history of MS attacks or deterioration in health status
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
This study is a randomised controlled trial designed to thoroughly investigate the effects of aerobic exercise on NVU biomarkers in individuals with MS. The study was conducted between February and June 2025 at the MS clinic affiliated with the Department of Neurology, Faculty of Medicine, Ondokuz Mayıs University. Participants were randomly assigned to either a control group or an exercise group. Assessments were conducted at baseline (pre-assessment) and eight weeks after the intervention (post-assessment).
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History
Started
Feb 2025
Main results due
Jun 2025
Finished
Jun 2025