Music-Augmented Rhythmic Gait Training in Multiple Sclerosis
Music-Augmented Versus Non-Music Technology-Based Rhythmic Gait Training in Multiple Sclerosis: A Randomized Controlled Trial of Gait Performance and Clinical Outcomes
What it found
No result yet.
What was tested
Treatment tested
- Music-Assisted Rhythmic Gait Training
Compared with
- Rhythmic Gait Training Without Music
Given to everyone in the trial
- Breathing and General Mobility Exercises
What it measured
Main measures
Gait Speed
Baseline and immediately after intervention
Disability progressionWalking and mobility
Other measures (8)
Two Minute Walk Test
Baseline and immediately after intervention
FatigueWalking and mobilitySafetyFeasibilityTimed Up and Go Test
Baseline and immediately after intervention
Walking and mobilityStep Length
Baseline and immediately after intervention
Walking and mobilityStride Length
Baseline and immediately after intervention
Walking and mobilityWalking Speed
Baseline and immediately after intervention
Walking and mobilityModified Fatigue Impact Scale
Baseline and immediately after intervention
Thinking and memoryFatigueThe Four Square Step Test
Baseline and immediately after intervention
Walking and mobilityBICAMS Battery
Baseline and immediately after intervention
Thinking and memory
Who could take part
MS (type not specified) · 18 to 65 · EDSS 0 to 4.0
Show the full criteria
Inclusion criteria
* Expanded Disability Status Scale (EDSS) score between 0 and 4.0 Access to the internet via a high-speed smartphone or computer A score of at least 21 on the Montreal Cognitive Assessment (MoCA) Functional Ambulation Scale score of Stage 3 or higher
Exclusion criteria
* Presence of hearing or visual impairments Current participation in any structured exercise program Presence of other neurological, cardiovascular, or orthopedic disorders History of MS relapse or change in disease-modifying treatment within the last 6 months Physical conditions preventing safe participation in the exercise program Comorbid conditions that adversely affect oxygen transport (e.g., severe anemia, peripheral arterial disease)
As registered. Criteria can change, so ask the trial team or your neurologist.
Contact details on the registryAbout this trial
In the sponsor's words
This randomized controlled trial aims to compare the effects of technology-based rhythmic gait training performed with and without music on walking performance and clinical outcomes in individuals with multiple sclerosis (MS). Thirty-two participants with mild to moderate disability will be randomly assigned to either a music-assisted rhythmic gait training group or a non-music control group, with both interventions delivered via telerehabilitation. Outcomes related to gait performance, balance, fatigue, and cognitive function will be assessed before and after a four-week intervention period.
Papers
Background
Benedetti MG, Piperno R, Simoncini L, Bonato P, Tonini A, Giannini S. Gait abnormalities in minimally impaired multiple sclerosis patients. Mult Scler. 1999 Oct;5(5):363-8. doi: 10.1177/135245859900500510.Background
Ehde DM, Elzea JL, Verrall AM, Gibbons LE, Smith AE, Amtmann D. Efficacy of a Telephone-Delivered Self-Management Intervention for Persons With Multiple Sclerosis: A Randomized Controlled Trial With a One-Year Follow-Up. Arch Phys Med Rehabil. 2015 Nov;96(11):1945-58.e2. doi: 10.1016/j.apmr.2015.07.015. Epub 2015 Aug 6.Background
Conklyn D, Stough D, Novak E, Paczak S, Chemali K, Bethoux F. A home-based walking program using rhythmic auditory stimulation improves gait performance in patients with multiple sclerosis: a pilot study. Neurorehabil Neural Repair. 2010 Nov-Dec;24(9):835-42. doi: 10.1177/1545968310372139. Epub 2010 Jul 19.
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History
Started
Jan 2026
Main results due
Jun 2026
Finished
Jul 2026