Exercise With and Without Cognitive Training

The Effect of Exercise With and Without Cognitive Training on Gait in Older Veterans With Multiple Sclerosis

Not yet recruitingNot a drug-phase studyMS (type not specified)NCT07447115

What it found

Still running

No result yet.

What was tested

Treatment tested

  • Effect of Exercise with and Without Cognitive Training on Gait

What it measured

Main measures

  • Gait speed

    Baseline & 10-week Follow-up

    Walking and mobility

  • Exit questionnaire

    10-week Follow-up

    Walking and mobilityPhysical functionMood and sleepQuality of life (reported by participants)

Other measures (10)

  • Static Postural Control

    Baseline & 10-week Follow-up

    Walking and mobility

  • Symbol Digit Modality Test

    Baseline & 10-week Follow-up

    Thinking and memory

  • California Verbal Learning Test

    Baseline & 10-week Follow-up

    Thinking and memory

  • Falls efficacy scale (FES)

    Baseline & 10-week Follow-up

    Walking and mobility

  • Number of falls per month

    1 year follow up after intervention, e.g., at 15 months.

    Walking and mobility

  • Brain-derived neurotrophic factor

    Baseline & 10-week Follow-up

  • Tumor necrosis alpha

    Baseline & 10-week Follow-up

  • Interleukin-6

    Baseline & 10-week Follow-up

    Immune response

  • Time to complete the Timed Up and Go

    Baseline & 10-week Follow-up

    Walking and mobility

  • Brief Visuospatial Memory Test

    Baseline & 10-week Follow-up

    Thinking and memory

Who could take part

MS (type not specified) · 55 to 85

Show the full criteria

Inclusion criteria

* US Veteran * Diagnosis of Multiple Sclerosis * Relapse free in the last 30 days * Capable of standing unaided for at least 1 minute * Expanded Disability Status Scale \<6.5 * Ability to speak and understand English

Exclusion criteria

* Any neurological disorder other than MS * Modified Telephone Interview for Cognitive Status \<20 * Current participation in an exercise or cognitive rehabilitation study

As registered. Criteria can change, so ask the trial team or your neurologist.

Contact details on the registry

About this trial

In the sponsor's words

This proposal aims to conduct a 10-week randomized controlled trial comparing walking and resistance training with and without computerized cognitive training in older Veterans with Multiple Sclerosis, followed by 12 months of fall tracking with sensors and fall calendars. The primary objectives of this proposed CDA2 are to provide critical preliminary data on 1) the feasibility of conducting a 10-week RCT, 2) preliminary treatment effects on gait, cognition, and falls, and 3) neuroinflammatory biomarkers. Dr. Katherine Hsieh will receive hands-on training in the design and conduct of clinical trials (Dr. Hackney), mechanisms underlying physical activity, cognitive rehabilitation, and falls (Drs. Twamley, Hackney, \& Kesar), fall detection technology (Prof. Sanford), and clinical problems faced by MS participants (Dr. Backus) to achieve her long-term career goal of becoming an independent falls prevention investigator.

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History

    1. Started

      Jan 2027

    2. Main results due

      Jan 2028

    3. Finished

      May 2028

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