Effectiveness of TMS on Spasticity and Balance for Patients With MS
The Effect of Transcranial Magnetic Stimulation on Spasticity and Balance in Patients Diagnosed With Multiple Sclerosis
What it found
No result yet.
What was tested
Treatment tested
- rTMS
Placebo
- sham rTMS
What it measured
Main measures
Modified Ashworth Scale
patients will be checked on first day of hospitalization, after treatment at 2 weeks and after treatment 1 month
SpasticityPenn Spasm Frequency Scale
patients will be checked on first day of hospitalization, after treatment at 2 weeks and after treatment 1 month
SpasticityModified Tardieu Scale
patients will be checked on first day of hospitalization, after treatment at 2 weeks and after treatment 1 month
FatigueBERG Balance Scale
patients will be checked on first day of hospitalization, after treatment at 2 weeks and after treatment 1 month
Walking and mobilityGoal Attainment Scale
patients will be checked on first day of hospitalization and after treatment 1 month
Spasticity
Other measures (5)
Visual Analogue Scale (VAS)
patients will be checked on first day of hospitalization, after treatment at 2 weeks and after treatment 1 month
PainExpanded Disability Status Scale (EDSS)
patients will be checked on first day of hospitalization, after treatment at 2 weeks and after treatment 1 month
Disability progressionVisionWalking and mobilityFunctional Independence Measure (FIM)
patients will be checked on first day of hospitalization, after treatment at 2 weeks and after treatment 1 month
Thinking and memoryMultiple Sclerosis Quality of Life-54 (MSQoL-54)
patients will be checked on first day of hospitalization, after treatment at 2 weeks and after treatment 1 month
Thinking and memoryFatigueBladder, bowel and sexual functionPainQuality of life (reported by participants)Six Minute Walk Test
patients will be checked on first day of hospitalization, after treatment at 2 weeks and after treatment 1 month
Walking and mobility
Who could take part
MS (type not specified) · 18 to 60 · EDSS 0 to 6.5
Show the full criteria
Inclusion criteria
* Being between the ages of 18 and 60 * Having been diagnosed with multiple sclerosis for more than six months * Having spasticity levels between 1 and 3 on the Modified Ashworth Scale (MAS) in the evaluated extremity * Having an EDSS SCORE between 0 and 6.5 * Voluntarily participating in the study
Exclusion criteria
* Poor general health (heart failure, COPD, etc.) * Presence of wound lesions on the skin * Presence of metal implants in the body * Pregnancy * Presence of a severe infection * Diagnosis of malignancy * Presence of a bleeding disorder * Use of a pacemaker * Presence of cardiac rhythm disorder * Presence of neurological disease other than multiple sclerosis * History of epilepsy * History of alcohol use * Change in medication within the last 6 months * Refusal to participate in the study
As registered. Criteria can change, so ask the trial team or your neurologist.
Contact details on the registryAbout this trial
In the sponsor's words
Recently, non-invasive brain stimulation modalities such as transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation have become treatment options. Among these methods, rTMS is a non-invasive brain stimulation technique that can affect descending corticospinal pathways, thereby modulating cortical excitability in the motor area where it is applied. This study will examine the effect of rTMS application on spasticity and balance in patients with multiple sclerosis. In addition, the indirect effects of the applications on gait pattern, joint range of motion, and pain will be evaluated.
Papers
Background
Zhou X, Li K, Chen S, Zhou W, Li J, Huang Q, Xu T, Gao Z, Wang D, Zhao S, Dong H. Clinical application of transcranial magnetic stimulation in multiple sclerosis. Front Immunol. 2022 Sep 5;13:902658. doi: 10.3389/fimmu.2022.902658. eCollection 2022.Background
Boutiere C, Rey C, Zaaraoui W, Le Troter A, Rico A, Crespy L, Achard S, Reuter F, Pariollaud F, Wirsich J, Asquinazi P, Confort-Gouny S, Soulier E, Guye M, Pelletier J, Ranjeva JP, Audoin B. Improvement of spasticity following intermittent theta burst stimulation in multiple sclerosis is associated with modulation of resting-state functional connectivity of the primary motor cortices. Mult Scler.Background
San AU, Yilmaz B, Kesikburun S. The Effect of Repetitive Transcranial Magnetic Stimulation on Spasticity in Patients with Multiple Sclerosis. J Clin Neurol. 2019 Oct;15(4):461-467. doi: 10.3988/jcn.2019.15.4.461.
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History
Started
Mar 2026
Main results due
Oct 2026
Finished
Nov 2026