Using Motor Imagery-based Brain-computer Interface With Multiple Scler
Clinical Investigation Into the Use of a Motor Imagery-based Brain-computer Interface for Rehabilitation Support in Patients With Multiple Sclerosis.
What it found
No result yet.
What was tested
Treatment tested
- Brain Computer Interface
What it measured
Main measures
Modulation of ERD/ERS patterns during Motor Imagery (MI) tasks
From baseline to week 12
MRI lesionsArm and hand function
Other measures (1)
System Usability and User Acceptance
Week 12 (end of treatment)
Quality of life (reported by participants)Feasibility
Who could take part
MS (type not specified) · 18 to 60
Show the full criteria
Inclusion criteria
* Clinical diagnosis of multiple sclerosis according to McDonald criteria 2017 (Thompson, 2018) * Age between 18 and 60 years * No clinical or radiological relapses in the 3 months prior to enrollment * Mild spasticity, defined as a score ≤1 on the Modified Ashworth Scale * Preserved cognitive function, defined as MMSE ≥ 24 * Ability to understand and independently sign informed consent
Exclusion criteria
* MMSE \< 24 * Presence of neurological or psychiatric comorbidities that may interfere with the intervention or understanding of procedures * Severe visual deficits or upper limb orthopedic conditions preventing task execution or EEG cap use * Dermatological, cranial, or other conditions contraindicating EEG cap use (e.g., active scalp lesions, known allergy to electrode materials, recent neurosurgical procedures) * Any clinical condition deemed by the physician to be incompatible with participation or patient safety
As registered. Criteria can change, so ask the trial team or your neurologist.
Contact details on the registryAbout this trial
In the sponsor's words
The goal of this clinical trial is to evaluate the effectiveness of a wearable brain-computer interface (BCI)-based neurofeedback system using motor imagery (MI) to support upper limb motor rehabilitation in patients with Multiple Sclerosis (MS). The main questions it aims to answer are: Does BCI-mediated neurofeedback enhance the voluntary modulation of sensorimotor rhythms (ERD/ERS) during motor imagery tasks in MS patients? Is the proposed BCI system usable, acceptable, and potentially suitable for telerehabilitation contexts? Researchers will compare a group undergoing BCI-based neurofeedback plus conventional motor therapy with a control group receiving only standard rehabilitation, to determine whether the intervention leads to superior EEG modulation and clinical outcomes. Participants will: Undergo 24 neurofeedback sessions over 12 weeks (2 per week), (experimental group), or do not receive any therapy (control group); Complete baseline and follow-up evaluations (6 weeks, 12 weeks, and 1-month post-treatment) including motor imagery ability (MIQ-3), manual dexterity (9-Hole Peg Test, AMSQ), perceived fatigue (FSS), and usability (SUS); Perform EEG-based motor imagery tasks with visual and haptic feedback in immersive extended reality (experimental group only).
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History
Started
Jul 2026
Main results due
Sept 2026
Finished
Nov 2026