Does Remotely Delivered Pilates Influence Physical and Psychological Outcomes in Individuals With Multiple Sclerosis?

RecruitingNot a drug-phase studyMS (type not specified)NCT07504120

What it found

Still running

No result yet.

What was tested

Treatment tested

  • Pilates

What it measured

Main measures

  • Change from baseline in walking endurance (Six-Minute Walk Test distance)

    Baseline and 16 weeks (end of treatment)

    Walking and mobility
  • Change from baseline in walking speed (Timed 25-Foot Walk)

    Baseline and 16 weeks (end of treatment)

    Disability progressionWalking and mobility
  • Change from baseline in balance (Berg Balance Scale)

    Baseline and 16 weeks (end of treatment)

    Walking and mobility
  • Change from baseline in fatigue (Fatigue Severity Scale)

    Baseline and 16 weeks (end of treatment)

    Fatigue
  • Change from baseline in pain (Short-form McGill Pain Questionnaire)

    Baseline and 16 weeks (end of treatment)

    Pain

Other measures (6)

  • Change from baseline in cognitive processing speed (Symbol Digit Modalities Test)

    Baseline and 16 weeks (end of treatment)

    Thinking and memory
  • Change from baseline in verbal learning and memory (California Verbal Learning Test-II)

    Baseline and 16 weeks (end of treatment)

    Thinking and memory
  • Change from baseline in visuospatial learning and memory (Brief Visuospatial Memory Test-Revised)

    Baseline and 16 weeks (end of treatment)

    Thinking and memory
  • Change from baseline in depression symptoms

    Baseline and 16 weeks (end of treatment)

    Mood and sleep
  • Change from baseline in anxiety symptoms

    Baseline and 16 weeks (end of treatment)

    Mood and sleep
  • Change from baseline in health-related quality of life

    Baseline and 16 weeks (end of treatment)

    Quality of life (reported by participants)

Who could take part

MS (type not specified) · 18 and over

Show the full criteria

Inclusion criteria

* Age 18 years or older * Self-reported diagnosis of multiple sclerosis by a neurologist * Relapse-free for the past 30 days before screening * Able to speak and read English as the primary language * Access to the internet and e-mail, * Ability to use Zoom, and willingness to complete testing sessions and questionnaires * Ambulatory without an assistive device (for example, cane) * Low to moderate disability, defined as a score of 0-4 on the Patient-Determined Disease Steps (PDDS) * Insufficiently active, defined as a score \< 14 on the Godin Leisure-Time Exercise Questionnaire-Health Contribution Score (GLTEQ-HCS) * Adequate visual ability and literacy to read materials printed in 14-point font * Currently treated with a disease-modifying therapy

Exclusion criteria

* Pregnant * Elevated risk for strenuous or maximal exercise, defined as more than one "Yes" response on the Physical Activity Readiness Questionnaire (PAR-Q) during screening

As registered. Criteria can change, so ask the trial team or your neurologist.

Contact details on the registry

About this trial

In the sponsor's words

Objectives Objective 1: To determine the effects of a 16-week remotely delivered Pilates intervention on walking endurance, walking speed, balance, fatigue, and pain compared to a waitlist control group in individuals with MS. Objective 2: To examine the impact of a 16-week remotely delivered Pilates intervention on depression \& anxiety, cognitive function, and QOL compared to a waitlist control group in individuals with MS. Aim Aim 1: To assess whether the 16-week remotely delivered Pilates intervention significantly improves walking endurance, walking speed, balance, fatigue, and pain compared to a waitlist control group in individuals with MS Aim 2: To investigate whether the 16-week remotely delivered Pilates intervention significantly improves depression \& anxiety, cognitive function, and QOL compared to a waitlist control group in individuals with MS. Hypothesis Hypothesis 1: The 16-week remotely delivered Pilates intervention will significantly improve walking endurance, walking speed, balance, fatigue, and pain compared to a waitlist control group in individuals with MS. Hypothesis 2: Participants receiving the 16-week remotely delivered Pilates intervention will demonstrate significantly greater improvements in depression \& anxiety, cognitive function, and QOL compared to a waitlist control group in individuals with MS.

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History

    1. Started

      Nov 2025

    2. Main results due

      Dec 2027

    3. Finished

      Dec 2027

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