The Effects of a 12-week In-phase Bilateral Exercise Programme on the
The Effects of a 12-week In-phase Bilateral Exercise Programme on the Corticospinal Plasticity in People With Progressive Multiple Sclerosis
We could not find results for this trial
What it found
We found no results in the registry or in papers.
This trial finished 16 months ago. We found no results in the registry or in any paper that cites it.
What was tested
Treatment tested
- In-Phase Bilateral Upper Limb Exercise Program
What it measured
Main measures
Active Motor Threshold
12 weeks
Myelin repairNerve conduction tests
Other measures (1)
Clinical Tests
12 weeks
Disability progressionThinking and memoryWalking and mobilityArm and hand functionPhysical function
Who could take part
Progressive MS · 30 to 75 · EDSS 5 to 7
Show the full criteria
Inclusion criteria
* Diagnosis of Primary Progressive Multiple Sclerosis (PPMS) or Secondary Progressive Multiple Sclerosis (SPMS) * Age between 30 and 75 years * Expanded Disability Status Scale (EDSS) score between 5 and 7 * Ability to understand study procedures and provide informed consent * Ability to safely participate in an exercise program involving coordinated upper-limb movements
Exclusion criteria
* Presence of other neurological diseases affecting the central nervous system (e.g., Parkinson's disease, stroke) * Metallic implants in the brain contraindicating transcranial magnetic stimulation (TMS) * History of significant cardiovascular disease (e.g., heart failure, aneurysm) * History of epilepsy or seizures * Severe orthopedic disorders (e.g., recent fractures, spine surgery, severe musculoskeletal injury) * Pregnancy during the study period * Severe visual impairments (e.g., optic neuritis, diplopia) * Severe hearing impairments (e.g., deafness) * Severe spasticity greater than grade 1+ on the Modified Ashworth Scale * Severe psychiatric disorders (e.g., schizophrenia)
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
This study investigates whether a structured exercise program using coordinated movements of both arms can improve brain and motor function in people with Progressive Multiple Sclerosis (MS). Progressive MS is associated with gradual worsening of neurological function, including difficulties with movement, strength, balance, and cognition. Because current medications have limited effects on disease progression, rehabilitation strategies that promote brain plasticity and functional recovery are increasingly important. In this study, five individuals with Progressive Multiple Sclerosis participated in a 12-week exercise program consisting of in-phase bilateral upper-limb movements performed three times per week. Brain activity related to movement was measured using transcranial magnetic stimulation (TMS), which assessed corticospinal excitability through active motor threshold measurements. Additional clinical tests evaluated walking speed, balance, hand dexterity, muscle strength, cognitive processing speed, fatigue, and quality of life. The study used a single-case experimental design with repeated measurements during baseline and intervention phases to determine whether the exercise program produced measurable neurophysiological and functional changes.
Papers
Loading reviews and guidelines…
History
Started
Feb 2025
Main results due
Jun 2025
Finished
Jun 2025