The Effects of High-Intensity Interval Training on Gait, Balance, and

Investigating the Effects of High-Intensity Interval Training on Gait, Balance, and Cognition in Individuals With Multiple Sclerosis

Not yet recruitingNot a drug-phase studyMS (type not specified)NCT07578740

What it found

Still running

No result yet.

What was tested

Treatment tested

  • High-Intensity Interval Training (HIIT)

Compared with

  • Moderate-Intensity Continuous Training (MICT)

What it measured

Main measures

  • Timed Up and Go Test (TUG)

    Baseline and 8 weeks

    Walking and mobility

Other measures (10)

  • Timed 25-Foot Walk Test (T25FW)

    Baseline and 8 weeks

    Disability progressionWalking and mobility

  • Dynamic Gait Index (DGI)

    Baseline and 8 weeks

    Walking and mobility

  • Incremental Shuttle Walk Test (ISWT)

    Baseline and 8 weeks

    Walking and mobilityPhysical function

  • Mini Balance Evaluation Systems Test (Mini-BESTest)

    Baseline and 8 weeks

    Walking and mobility

  • Modified CTSIB (mCTSIB) - Static Posturography

    Baseline and 8 weeks

    Walking and mobility

  • Serum BDNF levels (ELISA)

    Baseline and 8 weeks

  • Serum VEGF levels (ELISA)

    Baseline and 8 weeks

  • Symbol Digit Modalities Test (SDMT)

    Baseline and 8 weeks

    Thinking and memory

  • California Verbal Learning Test-II (CVLT-II)

    Baseline and 8 weeks

    Thinking and memory

  • Brief Visuospatial Memory Test-Revised (BVMT-R)

    Baseline and 8 weeks

    Thinking and memory

Who could take part

MS (type not specified) · 18 and over · EDSS 0 to 4

Show the full criteria

Inclusion criteria

* Diagnosed with Multiple Sclerosis by a neurologist (Hacettepe University Hospitals, Neurology Outpatient Clinic) * Age 18 years and older * EDSS score between 0 and 4 * Score of 24 or above on the Standardized Mini Mental State Examination * No relapse in the past 3 months * Medically stable for at least 6 months

Exclusion criteria

• Any additional cardiopulmonary, neurological, or systemic disease other than MS

As registered. Criteria can change, so ask the trial team or your neurologist.

Contact details on the registry

About this trial

In the sponsor's words

This study aims to comparatively investigate the effects of low-volume High-Intensity Interval Training (HIIT) versus Moderate-Intensity Continuous Training (MICT) on gait, balance, cognitive functions, and neurovascular biomarkers (BDNF, VEGF) in individuals with Multiple Sclerosis (MS). This randomized controlled trial will be conducted at Hacettepe University, Faculty of Physical Therapy and Rehabilitation.

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History

    1. Started

      Nov 2026

    2. Main results due

      Jun 2028

    3. Finished

      Jun 2028

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