PIONEER-1
What it found
No result yet.
What was tested
Treatment tested
- Privosegtor
- Methylprednisolone
Glucocorticoid receptor agonist
Placebo or sham
- Placebo
What it measured
Main measures
Proportion of participants achieving at least 15-letter gain from baseline in low contrast visual acuity (LCVA).
3 months
Vision
Other measures (4)
Proportion of participants achieving at least 30-letter gain from baseline in low contrast visual acuity (LCVA).
3 months
VisionMean change from baseline in low contrast visual acuity (LCVA).
3 months
VisionMean change from baseline in the ganglion cell - inner plexiform layer (GCIPL) thickness.
3 months
Retina scans (OCT)Serum neurofilament light chain (sNfL) mean change from baseline.
Through month 3
Blood or spinal fluid markers
Who could take part
Optic neuritis · 18 to 50
Key Inclusion Criteria: * Adult men and women (aged 18 to 50 years) with the first episode of ON in the study eye, associated with unilateral visual loss. * Onset of visual loss symptoms in the previous 12 days before first administration of study treatment. Key Exclusion Criteria: - Have a history or presence of any disorder or condition that may, in the opinion of the Investigator, likely interfere with the interpretation of the study results or participant safety
As registered. Criteria can change, so ask the trial team or your neurologist.
Contact details on the registryAbout this trial
In the sponsor's words
The goal of this clinical trial is to evaluate the safety and efficacy of privosegtor, a neuroprotective candidate, in patients diagnosed with optic neuritis (ON). Researchers will compare privosegtor and the standard of care (methylprednisolone) to a placebo and standard of care (methylprednisolone).
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History
Started
May 2026
Main results due
Dec 2027
Finished
Dec 2028
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