Coupled Gentamicin-Lactobacillus Rhamnosus in NLUTD
Effect of Dose Timing of Coupled Intravesical Gentamicin and Lactobacillus Rhamnosus LGG on Success and Length of Colonization in Men and Women With SCI/D and NLUTD
What it found
No result yet.
What was tested
Treatment tested
- Gentamicin
- Lactobacillus Rhamnosus GG
What it measured
Main measures
Level of Lactobacillus rhamnosus GG in Urine
24 hours after final LGG instillation
Other measures (1)
Length of Recolonization
28 days after final Lactobacillus instillation
Who could take part
MS (type not specified) · 18 and over
Show the full criteria
Inclusion criteria
* Neurologic diagnosis * ≥18 years old * Neurogenic bladder for at least 6 months * No USQNB-IC A, B1, or B2 symptoms * No currently diagnosed UTI (within 24 hours of initiating instillations) * Community dwelling (not in acute hospital setting)
Exclusion criteria
* Known genitourinary pathology beyond NLUTD (i.e. kidney stones, bladder stones, vesicoureteral reflux, etc.) * Use of prophylactic antibiotics or any antibiotics within 2 weeks of beginning instillations * Instillation of intravesical agents other than saline bladder wash * Immunodeficiency * Psychologic or psychiatric conditions influencing the ability to follow instructions * Allergy to ampicillin, daptomycin, gentamicin/gentamycin, or probiotics * Participation in another study which could confound results
As registered. Criteria can change, so ask the trial team or your neurologist.
Contact details on the registryAbout this trial
In the sponsor's words
The main objective of the proposed research study is to determine in men and women with spinal cord injury/disease and neurogenic bladder whether the dose of coupled gentamicin \& Lactobacillus rhamnosus GG affects the recolonization of the bladder, and whether the rate of success differs by sex. Secondary objectives include determining whether that recolonization lasts 7, 14, or 28 days; and safety of the coupled gentamicin \& Lactobacillus instillations.
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History
Started
Aug 2026
Main results due
Sept 2027
Finished
Sept 2027