Inspiratory Muscle Training in Individuals With Multiple Sclerosis
Comparison of the Effects of High-Intensity and Low-Intensity Inspiratory Muscle Training in Individuals With Multiple Sclerosis
What it found
No result yet.
What was tested
Treatment tested
- High intensity interval IMT
- Low intensity IMT
Compared with
- Conventional rehabilitation
What it measured
Main measures
Maximal inspiratory pressure (MIP)
From baseline to the end of the intervention at 8 weeks
Physical functionMaximal expiratory pressure (MEP)
From baseline to the end of the intervention at 8 weeks
Physical functionNerve conduction testsForced Vital Capacity (FVC)
From baseline to the end of the intervention at 8 weeks
Forced Expiratory Volume (FEV1)
From baseline to the end of the intervention at 8 weeks
Tiffeneau Index (FEV1/FVC)
From baseline to the end of the intervention at 8 weeks
Peak Expiratory Flow (PEF)
From baseline to the end of the intervention at 8 weeks
Cough strength
From baseline to the end of the intervention at 8 weeks
Physical function
Other measures (7)
Exercise capacity
From baseline to the end of the intervention at 8 weeks
Walking and mobilityPhysical functionLower Extremity Functional Capacity
From baseline to the end of the intervention at 8 weeks
Balance
From baseline to the end of the intervention at 8 weeks
Walking and mobilityFatigue level
From baseline to the end of the intervention at 8 weeks
FatigueDysphagia severity
From baseline to the end of the intervention at 8 weeks
Sleep quality
From baseline to the end of the intervention at 8 weeks
Mood and sleepThe Multiple Sclerosis Quality of Life-54 (MSQOL-54)
From baseline to the end of the intervention at 8 weeks
Thinking and memoryFatigueBladder, bowel and sexual functionPainQuality of life (reported by participants)
Who could take part
MS (type not specified) · 18 to 65
Show the full criteria
Inclusion criteria
* Diagnosis of multiple sclerosis (MS) according to the 2024 McDonald criteria * Expanded Disability Status Scale (EDSS) score ≥2 and \<6 * Age between 18 and 65 years * Mini-Mental State Examination (MMSE) score >24 * Willingness to participate in the study
Exclusion criteria
* Experiencing an MS relapse within the past three months * Presence of chronic cardiac or pulmonary diseases that may affect respiratory muscle strength and function, such as COPD, asthma, interstitial lung disease, or heart failure * Presence of pulmonary infection * Presence of orthopedic problems * Presence of psychiatric disorders * Pregnancy
As registered. Criteria can change, so ask the trial team or your neurologist.
Contact details on the registryAbout this trial
In the sponsor's words
Multiple sclerosis (MS) is a chronic disease affecting the central nervous system, characterized by inflammation, demyelination, and axonal degeneration, and primarily affects young adults. Muscle weakness, sensory disturbances, spasticity, pain, visual impairment, ataxia, fatigue, cognitive dysfunction, and respiratory complications are among the most commonly reported symptoms in individuals with MS. Although inspiratory muscle training has been shown to have beneficial effects in individuals with MS, the effects of different inspiratory muscle training intensities on respiratory muscle strength and pulmonary function have not been sufficiently investigated. The primary aim of this study is to investigate the effectiveness and clinical feasibility of high-intensity interval inspiratory muscle training in individuals with MS. The secondary aim is to compare the effects of high-intensity interval inspiratory muscle training, low-intensity inspiratory muscle training, and conventional rehabilitation on respiratory muscle strength, pulmonary function, cough effectiveness, exercise capacity, lower extremity functional muscle strength, balance, fatigue, dysphagia severity, sleep quality, and quality of life in individuals with MS. Participants will be randomly assigned to one of three groups: a high-intensity interval inspiratory muscle training group, a low-intensity inspiratory muscle training group, or a conventional rehabilitation group. All three groups will receive conventional rehabilitation, while the inspiratory muscle training groups will additionally receive their respective inspiratory muscle training programs. This study aims to be the first randomized controlled trial to evaluate the effects of high-intensity interval inspiratory muscle training in individuals with MS.
Loading reviews and guidelines…
History
Started
Aug 2026
Main results due
Aug 2027
Finished
Jan 2028