Simultaneous T2-FLAIR and T1 Brain MRI With ENRAGED FLAIR in Multiple
Evaluation of a Combined MR Sequence for Simultaneous T2- and T1-Weighted Brain Imaging in Multiple Sclerosis
What it found
We found no results in the registry or in papers.
What was tested
Treatment tested
- ENRAGED FLAIR MRI
What it measured
Main measures
MRI Acquisition Time
From start to completion of each MRI acquisition used for the scan-time comparison, assessed up to 1 day.
MRI lesions
Other measures (4)
T2-FLAIR Relative Diagnostic Image Quality Score on a 5-Point Preference Scale
At image review after the MRI examination, up to 12 months after enrollment
MRI lesionsT1-Weighted Relative Diagnostic Image Quality Score on a 5-Point Preference Scale
At image review after the MRI examination, up to 12 months after enrollment.
MRI lesionsMS Lesion Volume Agreement
After image processing and analysis, up to 12 months after enrollment
MRI lesionsAutomatic Brain Segmentation Agreement
After image processing and analysis, up to 12 months after enrollment
MRI lesions
Who could take part
MS (type not specified) · 18 and over
Show the full criteria
Inclusion criteria
* Adult patients, 18 years of age or older * Diagnosis of multiple sclerosis * Scheduled for a clinical brain MRI examination including T2-FLAIR and T1-weighted imaging * Able to provide written informed consent
Exclusion criteria
* Age under 18 years * Severe claustrophobia or inability to tolerate the additional MRI acquisition time * Inability to provide written informed consent
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
This study will evaluate a new brain MRI technique called ENRAGED FLAIR in patients with multiple sclerosis. MRI is central in the diagnosis and follow-up of multiple sclerosis because it can show inflammatory lesions in the brain. A standard MS brain MRI examination usually includes T2-FLAIR images, which are used to detect and assess MS lesions, and T1-weighted images, which provide anatomical information and help with interpretation of lesion location. These image types are usually acquired as separate scans. ENRAGED FLAIR is designed to acquire both T2-FLAIR and T1-weighted images during the same MRI sequence. The purpose of this study is to compare ENRAGED FLAIR with standard clinical MRI in patients with multiple sclerosis. Adult patients with multiple sclerosis who are already scheduled for a clinical brain MRI may be asked to participate. Participants will undergo one additional MRI sequence during the same visit. No extra contrast agent will be given, and no extra visit is required. The additional scan is expected to increase the examination time by about 5 to 10 minutes. The study will assess whether ENRAGED FLAIR provides image quality and MS lesion visualization comparable to standard MRI. If successful, this technique may help shorten future MRI examinations for patients with multiple sclerosis while preserving clinically useful image information.
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History
Started
Aug 2026
Main results due
Aug 2026
Finished
Aug 2026