Online Mindfulness-Based Cognitive Therapy for People With Multiple Sc
Online Mindfulness-Based Cognitive Therapy for People With Multiple Sclerosis With Mild-Moderate Depression: A Hybrid Effectiveness-Implementation Study
What it found
No result yet.
What was tested
Treatment tested
- Mindfulness-Based Cognitive Therapy
What it measured
Main measures
Depression
Baseline (T0), immediately post MBCT (T1), and 3 months later (T2)
Mood and sleep
Other measures (16)
Self-efficacy
Baseline (T0), immediately post MBCT (T1), and 3 months later (T2)
Self-management
Baseline (T0), immediately post MBCT (T1), and 3 months later (T2)
Stigma
Baseline (T0), immediately post MBCT (T1), and 3 months later (T2)
Fatigue
Baseline (T0), immediately post MBCT (T1), and 3 months later (T2)
FatigueSleep
Baseline (T0), immediately post MBCT (T1), and 3 months later (T2)
Mood and sleepChange in pain
Baseline (T0), immediately post MBCT (T1), and 3 months later (T2)
PainChange in quality of life
Baseline (T0), immediately post MBCT (T1), and 3 months later (T2)
Quality of life (reported by participants)Anxiety
Baseline (T0), immediately post MBCT (T1), and 3 months later (T2)
Mood and sleepMindfulness
Baseline (T0), immediately post MBCT (T1), and 3 months later (T2)
Self-compassion
Baseline (T0), immediately post MBCT (T1), and 3 months later (T2)
Who could take part
MS (type not specified) · 18 and over
Show the full criteria
Inclusion criteria
Inclusion criteria will include: * Age >/=18 * Neurologist confirmed MS diagnosis (McDonald criteria) * Able to understand spoken and written English * A score of 14-28 on the Beck Depression Inventory-II signifying mild-moderate depression * Registered with a primary care provider (family physician or neurologist) * Residing in Canada Exclusion criteria will include: * Potentially life-threatening comorbidities (suicidal ideation (i.e., score of 2 or 3 on the BDI-Fast Screen suicidal ideation question), history of psychosis, terminal/life threatening inter-current illness), or those such conditions expected to significantly limit participation and adherence (pregnancy, cognitive impairment i.e. score \<26 on the Montreal Cognitive Assessment - MoCA) * Receipt of MBCT in the past 2 years (completed at least 4/8 sessions).
Exclusion criteria
Not separately supplied in the registry.
As registered. Criteria can change, so ask the trial team or your neurologist.
Contact details on the registryAbout this trial
In the sponsor's words
This study will use a waiting list randomized controlled trial design with a mixed-methods research approach, including both quantitative and qualitative methods. Randomization helps minimize research bias and controls for participant and contextual factors that might otherwise make interpretation of results challenging. We will recruit 152 people with multiple sclerosis (PwMS) with any type of MS, who also have mild-moderate depression, aged 18 or greater, and able to understand spoken and written English. For the quantitative part, we will examine how much change in depression there is following mindfulness-based cognitive therapy (MBCT), as well as whether participants attend the course and complete study measures or not, and how much participants complete MBCT home practices. We will also examine how much change there is in fatigue, sleep pain, quality of life, and anxiety. For the qualitative part of the study, we will use semi-structured interviews to explore participant experiences of online MBCT, how people used online MBCT, what worked, what didn't and why, how online MBCT impacted self-management of depression, and suggestions for improving the course to make it more relevant for PwMS with depression.
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History
Started
Aug 2026
Main results due
Nov 2028
Finished
Dec 2028