Music-4-MS to Improve Cognition in People Living With Multiple Scleros
A Randomized Controlled Trial of Music-4-MS Compared to Music Listening to Improve Cognition in People Living With Multiple Sclerosis: A Feasibility Study
What it found
No result yet.
What was tested
Treatment tested
- Music Training Intervention
Compared with
- Music Listening
What it measured
Main measures
Feasibility: Engagement
Immediately post-intervention
FeasibilityFeasibility: Retention
Immediately post-intervention
FeasibilityFeasibility: Recruitment
Immediately post-intervention
FeasibilityMusical Training Intervention Acceptability
Immediately post-intervention
FeasibilityMusic Listening Intervention Acceptability
Immediately post-intervention
Feasibility
Other measures (9)
Mean Change from Baseline in Functional Well-Being Scores at 12 weeks and 16 weeks
Immediately post-intervention and 1-month post-intervention
FatiguePainMood and sleepQuality of life (reported by participants)Mean Change from Baseline in Cognitive Function at 12 weeks and 16 weeks
Immediately post-intervention and 1-month post-intervention
Thinking and memoryQuality of life (reported by participants)Mean Change from Baseline in Upper Extremity Function Scores at 12 weeks and 16 weeks
Immediately post-intervention and 1-month post-intervention
Arm and hand functionQuality of life (reported by participants)Mean Change from Baseline in Objective Hand Dexterity Scores at 12 weeks and 16 weeks
Immediately post-intervention and 1-month post-intervention
Disability progressionArm and hand functionMean Change from Baseline in Subjective Hand Dexterity Scores at 12 weeks and 16 weeks
Immediately post-intervention and 1-month post-intervention
Arm and hand functionMean Change from Baseline in Loneliness Scores at 12 weeks and 16 weeks.
Immediately post-intervention and 1-month post-intervention
Mean Change from Baseline in Attention Scores at 12 weeks and 16 weeks
Immediately post-intervention and 1-month post-intervention
Thinking and memoryMean Change from Baseline in Memory Scores at 12 weeks and 16 weeks
Immediately post-intervention and 1-month post-intervention
Thinking and memoryMean Change from Baseline in Executive Functioning Scores at 12 weeks and 16 weeks
Immediately post-intervention and 1-month post-intervention
Thinking and memory
Who could take part
Relapsing and progressive · 18 to 80
Show the full criteria
Inclusion criteria
* Diagnosed with multiple sclerosis (relapsing remitting, secondary progressive, primary progressive) * Diagnosed more than 6 months prior to starting study * Self-reported cognitive impairment as assessed by having at leased 5 problems "sometimes" or more often on the Perceived Deficits Questionnaire * Read, write, and understand English * Access to internet
Exclusion criteria
* Diagnosed with another neurological condition that causes cognitive impairment * MS exacerbation within the last 30 days * Professional musician (primary source of income)
As registered. Criteria can change, so ask the trial team or your neurologist.
Contact details on the registryAbout this trial
In the sponsor's words
Multiple sclerosis (MS) rates in the U.S. have nearly doubled over the past decade, making it a leading cause of nontraumatic functional impairment in young adults and significantly affecting cognitive function in up to 70% of people with MS. While traditional cognitive rehabilitation methods are limited in sensory engagement, music training offers a multisensory approach that enhances neuroplasticity and improves cognitive functions. This study investigates the feasibility of Music-4-MS, a 12-week music-based eHealth intervention, to support cognitive and emotional health in individuals with MS.
Loading reviews and guidelines…
History
Started
Aug 2026
Main results due
Mar 2028
Finished
Aug 2028