Effects of Face-to-Face Versus Telerehabilitation-Based Circuit Traini
Effects of Face-to-Face Versus Telerehabilitation-Based Circuit Training in People With Multiple Sclerosis
What it found
No result yet.
What was tested
Treatment tested
- Face-to-Face Circuit Training
- Synchronous Telerehabilitation-Based Circuit Training
What it measured
Main measures
Walking Endurance: 6-Minute Walk Test (6MWT)
Baseline and post-intervention at Week 8
Walking and mobility
Other measures (8)
Walking Speed: Timed 25-Foot Walk Test (T25FW)
Baseline and post-intervention at Week 8
Disability progressionWalking and mobilityFunctional Mobility: Timed Up and Go Test (TUG)
Baseline and post-intervention at Week 8
Walking and mobilityDynamic Balance: Mini-Balance Evaluation Systems Test (Mini-BESTest)
Baseline and post-intervention at Week 8
Walking and mobilityLower-Extremity Functional Muscle Strength: Five Times Sit-to-Stand Test (5xSTS)
Baseline and post-intervention at Week 8
Physical functionSafetyPatient-Perceived Impact on Walking Ability: Multiple Sclerosis Walking Scale-12 (MSWS-12)
Baseline and post-intervention at Week 8
Walking and mobilityQuality of life (reported by participants)Fatigue: Modified Fatigue Impact Scale (MFIS)
Baseline and post-intervention at Week 8
Thinking and memoryFatigueQuality of life (reported by participants)Quality of Life: Multiple Sclerosis International Quality of Life Questionnaire (MusiQoL)
Baseline and post-intervention at Week 8
Quality of life (reported by participants)Physical and Psychological Impact of Multiple Sclerosis: Multiple Sclerosis Impact Scale-29 (MSIS-29)
Baseline and post-intervention at Week 8
Walking and mobilityQuality of life (reported by participants)
Who could take part
MS (type not specified) · 18 to 65 · EDSS 2.0 to 5.5
Show the full criteria
Inclusion criteria
* Diagnosis of multiple sclerosis Age between 18 and 65 years Expanded Disability Status Scale (EDSS) score between 2.0 and 5.5 Mini-Mental State Examination (MMSE) score greater than 24 No relapse within the past 3 months Ability to walk at least 100 meters with or without an assistive device Willingness to participate in the study and provision of written informed consent
Exclusion criteria
* Botulinum toxin treatment for spasticity or a surgical procedure within the past 6 months Participation in a regular physiotherapy or rehabilitation program within the past 3 months Presence of a secondary neurological, orthopedic, or systemic disease that prevents independent standing and walking Presence of severe peripheral vestibular dysfunction Presence of a medical condition that may prevent participation in exercise Failure to provide written informed consent
As registered. Criteria can change, so ask the trial team or your neurologist.
Contact details on the registryAbout this trial
In the sponsor's words
This randomized controlled study was planned to compare the effects of delivering the same exercise content face-to-face and through telerehabilitation in individuals diagnosed with multiple sclerosis. All participants will receive circuit training for 8 weeks. The program will consist of two sessions per week, each lasting approximately 60 minutes. Assessments will be performed before and after treatment. Participants will be divided into two groups according to the mode of delivery: face-to-face and telerehabilitation. Telerehabilitation sessions will be conducted synchronously (via live connection) twice a week. The study population will consist of adults aged 18-65 years with a diagnosis of MS who attend Istanbul University-Cerrahpaşa Hospital. Individuals who meet the eligibility criteria will be included in the study on a voluntary basis after being informed about the study. Participants will be allocated to the groups using stratified randomization based on EDSS scores. The circuit training program will consist of endurance-, resistance-, and balance-focused exercise components. The effects of the interventions will be evaluated in terms of walking endurance and speed, functional mobility, dynamic balance, lower-extremity functional muscle strength, perceived walking ability, fatigue, quality of life, and the physical and psychological impact of MS. All assessments will be performed before the intervention and at the end of the 8-week program.
Papers
Results
Chisari C, Venturi M, Bertolucci F, Fanciullacci C, Rossi B. Benefits of an intensive task-oriented circuit training in Multiple Sclerosis patients with mild disability. NeuroRehabilitation. 2014;35(3):509-18. doi: 10.3233/NRE-141144.Results
Lehmann I, Thaler I, Luder G, Damm U, Walti C, Steinheimer S, Verra ML, Muri RM, Nyffeler T, Vanbellingen T, Kamm CP. Standardized, comprehensive, hospital-based circuit training in people with multiple sclerosis: results on feasibility, adherence and satisfaction of the training intervention. Eur J Phys Rehabil Med. 2020 Jun;56(3):279-285. doi: 10.23736/S1973-9087.20.06191-2. Epub 2020 Mar 30.Results
Ozden F, Ozkeskin M, Yuceyar N. The reliability and validity of the Turkish version of the multiple sclerosis impact scale-29. Turk J Med Sci. 2022 Aug;52(4):1216-1222. doi: 10.55730/1300-0144.5426. Epub 2022 Aug 10.Results
Simeoni M, Auquier P, Fernandez O, Flachenecker P, Stecchi S, Constantinescu C, Idiman E, Boyko A, Beiske A, Vollmer T, Triantafyllou N, O'Connor P, Barak Y, Biermann L, Cristiano E, Atweh S, Patrick D, Robitail S, Ammoury N, Beresniak A, Pelletier J; MusiQol study group. Validation of the Multiple Sclerosis International Quality of Life questionnaire. Mult Scler. 2008 Mar;14(2):219-30. doi: 10.11Results
Armutlu K, Keser I, Korkmaz N, Akbiyik DI, Sumbuloglu V, Guney Z, Karabudak R. Psychometric study of Turkish version of Fatigue Impact Scale in multiple sclerosis patients. J Neurol Sci. 2007 Apr 15;255(1-2):64-8. doi: 10.1016/j.jns.2007.01.073. Epub 2007 Mar 6.Results
Dib H, Tamam Y, Terzi M, Hobart J. Testing patient-reported outcome measurement equivalence in multinational clinical trials: An exemplar using the 12-item Multiple Sclerosis Walking Scale. Mult Scler J Exp Transl Clin. 2017 Sep 1;3(3):2055217317728740. doi: 10.1177/2055217317728740. eCollection 2017 Jul-Sep.Results
Moller AB, Bibby BM, Skjerbaek AG, Jensen E, Sorensen H, Stenager E, Dalgas U. Validity and variability of the 5-repetition sit-to-stand test in patients with multiple sclerosis. Disabil Rehabil. 2012;34(26):2251-8. doi: 10.3109/09638288.2012.683479. Epub 2012 May 22.Results
Dogruoz Karatekin B, Icagasioglu A, Pasin O. Validity, reliability and minimal detectable change of Mini-BESTest Turkish version in neurological disorders. Acta Neurol Belg. 2023 Aug;123(4):1519-1525. doi: 10.1007/s13760-023-02299-7. Epub 2023 Jun 16.Results
Sebastiao E, Sandroff BM, Learmonth YC, Motl RW. Validity of the Timed Up and Go Test as a Measure of Functional Mobility in Persons With Multiple Sclerosis. Arch Phys Med Rehabil. 2016 Jul;97(7):1072-7. doi: 10.1016/j.apmr.2015.12.031. Epub 2016 Mar 2.Results
Motl RW, Cohen JA, Benedict R, Phillips G, LaRocca N, Hudson LD, Rudick R; Multiple Sclerosis Outcome Assessments Consortium. Validity of the timed 25-foot walk as an ambulatory performance outcome measure for multiple sclerosis. Mult Scler. 2017 Apr;23(5):704-710. doi: 10.1177/1352458517690823. Epub 2017 Feb 16.
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History
Started
Sept 2026
Main results due
Dec 2026
Finished
Feb 2027