High-Intensity Interval Training for Walking and Function Across Diffe
The Effect of High-Intensity Interval Training on Maximum Walking Distance and Functional Parameters in Patients With Multiple Sclerosis at Different Disability Levels
What it found
No result yet.
What was tested
Treatment tested
- High-Intensity Interval Training
What it measured
Main measures
Maximum Walking Distance
Assessed at baseline (pre-intervention), immediately post-intervention (at 8 weeks), and 4 weeks post-intervention (follow-up)
Walking and mobility
Other measures (7)
Fatigue
Baseline, immediately post-intervention, and 4 weeks follow-up
FatigueMuscle Strength
Baseline, immediately post-intervention, and 4 weeks follow-up
Physical functionMuscular Endurance
Baseline, immediately post-intervention, and 4 weeks follow-up
Gait Speed
Baseline, immediately post-intervention, and 4 weeks follow-up
Walking and mobilityHealth-Related Quality of Life
Baseline, immediately post-intervention, and 4 weeks follow-up
Quality of life (reported by participants)balance
Baseline, immediately post-intervention, and 4 weeks follow-up
Walking and mobilityDynamic Balance
Baseline, immediately post-intervention, and 4 weeks follow-up
Walking and mobility
Who could take part
MS (type not specified) · 18 to 65 · EDSS 0 to 6.5
Show the full criteria
Inclusion criteria
* Be between the ages of 18 and 65, * Have been diagnosed with MS by a treating physician, * Have an EDSS score between 0 and 6.5, * Not having experienced a relapse within the last 3 months, * Not having severe lower extremity contractures, severe spasticity (≥3 on the Modified Ashworth Scale), or an acute orthopedic problem that would prevent the participant from pedaling on a bicycle ergometer, * Having a Mini Mental State Examination score of ≥24.
Exclusion criteria
* Having a severe cardiovascular, orthopedic, respiratory, or metabolic disease, * Having an additional neurological condition, * Being pregnant or suspecting pregnancy, * Having received a botulinum toxin injection within the last 3 months, * Having a COMPASS-31 total score greater than 13.6
As registered. Criteria can change, so ask the trial team or your neurologist.
Contact details on the registryAbout this trial
In the sponsor's words
Multiple Sclerosis (MS) is a chronic neurological disease that can affect daily functioning, mobility, and overall quality of life. High-Intensity Interval Training (HIIT) is known to be a time-efficient exercise approach that improves exercise capacity and reduces fatigue in MS. However, current research lacks sufficient data on how HIIT affects individuals with different levels of disability. The main purpose of this study is to evaluate the effects of a stationary bicycle-based HIIT protocol on maximum walking distance, fatigue, balance, muscle strength, endurance, gait speed, and quality of life in MS patients across three different disability levels: mild, moderate, and severe (classified according to Expanded Disability Status Scale - EDSS scores). Participants will complete a cycle ergometer-based HIIT program. Assessments will be conducted at three time points: Before starting the exercise program (baseline) Immediately after completing the program (post-treatment) 4 weeks after the completion of the program (follow-up) To ensure unbiased results, a triple-blind design will be used, meaning the outcome assessor, the treating physiotherapist, and the data analyst will be blinded to group assignments. The findings aim to help clinicians tailor personalized, effective HIIT protocols based on a patient's specific disability level rather than using a standardized, one-size-fits-all approach in MS rehabilitation.
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History
Started
Sept 2026
Main results due
Dec 2027
Finished
Jan 2028