An Online Tailored Cognitive Therapy-Based Intervention for Depression
A Randomized Controlled Trial of an Online Tailored Cognitive Therapy Based Intervention For Depression in Multiple Sclerosis: ACTION-MS Online
What it found
No result yet.
What was tested
Treatment tested
- ACTION-MS website - an 8-week cognitive behavioural therapy intervention for depression.
Compared with
- The 'Health and Wellbeing in MS' website
What it measured
Main measures
Depression, measured on Beck's Depression Inventory II
Baseline, post intervention (8 weeks) and 28-weeks follow up
Mood and sleep
Who could take part
MS (type not specified) · 18 and over
Show the full criteria
Inclusion criteria
* Aged 18 years or older * Clinical diagnosis of multiple sclerosis (MS) * Reports mild to moderate depressive symptoms, defined as a score of 14-28 on the Beck Depression Inventory-II (BDI-II)
Exclusion criteria
* Gross cognitive impairment that would make participation in the eight online cognitive behavioural therapy (CBT) modules distressing or difficult * Inability to speak or read English * Acute organic brain syndrome (e.g., delirium) * A serious psychological disorder, including psychosis, bipolar disorder, or current substance use disorder, as determined by the Structured Clinical Interview for DSM-5 (SCID-5) * Severe depressive symptoms, defined as a BDI-II score of 29 or greater, as assessed using the BDI-II and SCID-5 Currently undertaking psychological treatment for depression and/or anxiety
As registered. Criteria can change, so ask the trial team or your neurologist.
Contact details on the registryAbout this trial
In the sponsor's words
Individuals with MS experience significantly high levels of depression which are higher than in any other chronic illness or neurological disorder. Depression can occur at any point in the course of the disease. Cognitive behavioural therapy (CBT) has been found to be effective in treating depression in people with MS. However, many individuals with MS who would benefit from CBT for depression do not participate in face-to-face treatment due to lack of clinician referral, accessibility, modality preference, cost, and mobility and travel issues due to health reasons. Given the acceptability and preference for telehealth treatment options, digital-based psychological interventions can be another appealing treatment option as these programs have the ability to deliver interactive CBT treatments for depression to individuals with MS at a time and location convenient to the individual. The current trial proposes to test the acceptability, effectiveness, satisfaction and cost-effectiveness of an 8-week online depression intervention targeting individuals with multiple sclerosis and compare this intervention with an 8-week online health and wellbeing in MS informational intervention.
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History
Started
Nov 2026
Main results due
Jun 2027
Finished
Jun 2027