Effects of Video Game-Based Exercise Training on Physical Activity, Balance, Fatigue, and Quality of Life in Pediatric-Onset Multiple Sclerosis Patients

Not yet recruitingNot a drug-phase studyMS (type not specified)NCT07257900

What it found

Still running

No result yet.

What was tested

Treatment tested

  • Structured Functional Exercise Program
  • Exergaming Rehabilitation

What it measured

Main measures

  • Timed Up and Go (TUG)

    Baseline and at 8 weeks

    Walking and mobility

Other measures (8)

  • Mini-BESTest

    Baseline and at 8 weeks

    Walking and mobility
  • 6 Minute Walk Test (6MWT)

    Baseline and at 8 weeks

    FatigueWalking and mobility
  • Five Times Sit-to-Stand (5xSTS)

    Baseline and at 8 weeks

    Walking and mobilityPhysical function
  • Pedometer (Omron HJ-321-E)

    Baseline and at 8 weeks

    Physical function
  • Godin Leisure-Time Exercise Questionnaire (GLTEQ)

    Baseline and at 8 weeks

    Physical function
  • Multiple Sclerosis Functional Composite (MSFC)

    Baseline and at 8 weeks

    Disability progressionThinking and memoryWalking and mobilityArm and hand function
  • Pediatric Quality of Life Multidimensional Fatigue Scale (PedsQL-MFS)

    Baseline and at 8 weeks

    Thinking and memoryFatigueMood and sleepQuality of life (reported by participants)
  • Pediatric Quality of Life Inventory (PedsQL)

    Baseline and at 8 weeks

    Quality of life (reported by participants)

Who could take part

MS (type not specified) · 12 to 22

Show the full criteria

Inclusion criteria

* Children and adolescents aged 12-22 years. * Diagnosed with pediatric-onset multiple sclerosisaccording to the 2017 revised McDonald criteria. * Expanded Disability Status Scale (EDSS) ≤ 6 * Participate in online exercise sessions via Zoom

Exclusion criteria

* Presence of orthopedic problems affecting mobility. * Blurred vision or visual disturbances that could interfere with exergaming or exercise performance. * Any comorbid medical, neurological, or psychiatric condition that could influence physical performance or study outcomes. * History of relapse or corticosteroid treatment within the last three months.

As registered. Criteria can change, so ask the trial team or your neurologist.

Contact details on the registry

About this trial

In the sponsor's words

This study will examine how two different exercise programs affect children and young adults with pediatric-onset multiple sclerosis (POMS). POMS is a type of multiple sclerosis that begins in childhood or adolescence and can cause fatigue, weakness, balance problems, and difficulty moving. This study aims to evaluate the effectiveness of a video game-based exercise program (exergaming) compared with traditional exercise training in enhancing balance, physical activity levels, reducing fatigue, and improving quality of life in individuals with pediatric-onset multiple sclerosis. Approximately 30 participants aged 12 to 22 years old who have been diagnosed with POMS and have mild to moderate symptoms (Extended Disability Status Scale [EDSS] score below 6) will participate in the study. Participants will be randomly assigned to one of two groups: Traditional Exercise Group: Participants will receive structured exercise instruction via live Zoom sessions (a tele-rehabilitation model). For 8 weeks, twice a week, they will perform supervised aerobic, strength, and balance exercises, each lasting approximately 45 minutes. Exercise Game Group: Participants will perform similar aerobic, strength training, and balance exercises using the Nintendo Switch Ring Fit Adventure™ video game system. Researchers will evaluate participants' physical activity levels, balance, fatigue, and quality of life parameters at baseline and after completing the 8-week intervention. The study aims to determine whether the exergaming program can help participants increase their physical activity, reduce fatigue, and improve balance and daily functioning compared with traditional exercise. This approach offers an engaging and technology-supported way to incorporate physical activity into the rehabilitation of young people with POMS.

Papers

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History

    1. Started

      Dec 2025

    2. Main results due

      Dec 2026

    3. Finished

      Dec 2027

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