Comparison of Structured Exercise and Exergaming in Pediatric-Onset Mu
Effects of Video Game-Based Exercise Training on Physical Activity, Balance, Fatigue, and Quality of Life in Pediatric-Onset Multiple Sclerosis Patients
What it found
No result yet.
What was tested
Treatment tested
- Structured Functional Exercise Program
- Exergaming Rehabilitation
What it measured
Main measures
Timed Up and Go (TUG)
Baseline and at 8 weeks
Walking and mobility
Other measures (8)
Mini-BESTest
Baseline and at 8 weeks
Walking and mobility6 Minute Walk Test (6MWT)
Baseline and at 8 weeks
FatigueWalking and mobilityFive Times Sit-to-Stand (5xSTS)
Baseline and at 8 weeks
Walking and mobilityPhysical functionPedometer (Omron HJ-321-E)
Baseline and at 8 weeks
Physical functionGodin Leisure-Time Exercise Questionnaire (GLTEQ)
Baseline and at 8 weeks
Physical functionMultiple Sclerosis Functional Composite (MSFC)
Baseline and at 8 weeks
Disability progressionThinking and memoryWalking and mobilityArm and hand functionPediatric Quality of Life Multidimensional Fatigue Scale (PedsQL-MFS)
Baseline and at 8 weeks
Thinking and memoryFatigueMood and sleepQuality of life (reported by participants)Pediatric Quality of Life Inventory (PedsQL)
Baseline and at 8 weeks
Quality of life (reported by participants)
Who could take part
MS (type not specified) · 12 to 22
Show the full criteria
Inclusion criteria
* Children and adolescents aged 12-22 years. * Diagnosed with pediatric-onset multiple sclerosisaccording to the 2017 revised McDonald criteria. * Expanded Disability Status Scale (EDSS) ≤ 6 * Participate in online exercise sessions via Zoom
Exclusion criteria
* Presence of orthopedic problems affecting mobility. * Blurred vision or visual disturbances that could interfere with exergaming or exercise performance. * Any comorbid medical, neurological, or psychiatric condition that could influence physical performance or study outcomes. * History of relapse or corticosteroid treatment within the last three months.
As registered. Criteria can change, so ask the trial team or your neurologist.
Contact details on the registryAbout this trial
In the sponsor's words
This study will examine how two different exercise programs affect children and young adults with pediatric-onset multiple sclerosis (POMS). POMS is a type of multiple sclerosis that begins in childhood or adolescence and can cause fatigue, weakness, balance problems, and difficulty moving. This study aims to evaluate the effectiveness of a video game-based exercise program (exergaming) compared with traditional exercise training in enhancing balance, physical activity levels, reducing fatigue, and improving quality of life in individuals with pediatric-onset multiple sclerosis. Approximately 30 participants aged 12 to 22 years old who have been diagnosed with POMS and have mild to moderate symptoms (Extended Disability Status Scale [EDSS] score below 6) will participate in the study. Participants will be randomly assigned to one of two groups: Traditional Exercise Group: Participants will receive structured exercise instruction via live Zoom sessions (a tele-rehabilitation model). For 8 weeks, twice a week, they will perform supervised aerobic, strength, and balance exercises, each lasting approximately 45 minutes. Exercise Game Group: Participants will perform similar aerobic, strength training, and balance exercises using the Nintendo Switch Ring Fit Adventure™ video game system. Researchers will evaluate participants' physical activity levels, balance, fatigue, and quality of life parameters at baseline and after completing the 8-week intervention. The study aims to determine whether the exergaming program can help participants increase their physical activity, reduce fatigue, and improve balance and daily functioning compared with traditional exercise. This approach offers an engaging and technology-supported way to incorporate physical activity into the rehabilitation of young people with POMS.
Papers
Background
Sebastiao E, Sandroff BM, Learmonth YC, Motl RW. Validity of the Timed Up and Go Test as a Measure of Functional Mobility in Persons With Multiple Sclerosis. Arch Phys Med Rehabil. 2016 Jul;97(7):1072-7. doi: 10.1016/j.apmr.2015.12.031. Epub 2016 Mar 2.Background
Boiko A, Vorobeychik G, Paty D, Devonshire V, Sadovnick D; University of British Columbia MS Clinic Neurologists. Early onset multiple sclerosis: a longitudinal study. Neurology. 2002 Oct 8;59(7):1006-10. doi: 10.1212/wnl.59.7.1006.Background
Grover SA, Sawicki CP, Kinnett-Hopkins D, Finlayson M, Schneiderman JE, Banwell B, Till C, Motl RW, Yeh EA. Physical Activity and Its Correlates in Youth with Multiple Sclerosis. J Pediatr. 2016 Dec;179:197-203.e2. doi: 10.1016/j.jpeds.2016.08.104. Epub 2016 Oct 4.Background
Weikert M, Motl RW, Suh Y, McAuley E, Wynn D. Accelerometry in persons with multiple sclerosis: measurement of physical activity or walking mobility? J Neurol Sci. 2010 Mar 15;290(1-2):6-11. doi: 10.1016/j.jns.2009.12.021. Epub 2010 Jan 8.Background
Yeh EA, Kinnett-Hopkins D, Grover SA, Motl RW. Physical activity and pediatric multiple sclerosis: Developing a research agenda. Mult Scler. 2015 Nov;21(13):1618-25. doi: 10.1177/1352458515606526. Epub 2015 Oct 7.Background
Moller AB, Bibby BM, Skjerbaek AG, Jensen E, Sorensen H, Stenager E, Dalgas U. Validity and variability of the 5-repetition sit-to-stand test in patients with multiple sclerosis. Disabil Rehabil. 2012;34(26):2251-8. doi: 10.3109/09638288.2012.683479. Epub 2012 May 22.Background
Chan WLS, Chan CWL, Chan HHW, Chan KCK, Chan JSK, Chan OLW. A randomised controlled pilot study of a Nintendo Ring Fit Adventure balance and strengthening exercise program in community-dwelling older adults with a history of falls. Australas J Ageing. 2024 Sep;43(3):533-544. doi: 10.1111/ajag.13297. Epub 2024 Feb 26.Background
Alba-Rueda A, Lucena-Anton D, De Miguel-Rubio A. Effectiveness of two different exergaming systems in addition to conventional treatment for physical therapy in patients with multiple sclerosis: A study protocol for a multicenter, assessor-blind, 24-week, randomized controlled trial. Digit Health. 2024 Oct 18;10:20552076241287874. doi: 10.1177/20552076241287874. eCollection 2024 Jan-Dec.Background
Grover SA, Aubert-Broche B, Fetco D, Collins DL, Arnold DL, Finlayson M, Banwell BL, Motl RW, Yeh EA. Lower physical activity is associated with higher disease burden in pediatric multiple sclerosis. Neurology. 2015 Nov 10;85(19):1663-9. doi: 10.1212/WNL.0000000000001939. Epub 2015 Aug 12.Background
Polizzi A, Rinella S, Ruggieri M, Gentile AE, Verrelli CM, Iosa M. Efficacy of videogames and exergames in pediatric neurorehabilitation: a systematic review. Minerva Pediatr (Torino). 2024 Oct;76(5):690-702. doi: 10.23736/S2724-5276.23.07146-X. Epub 2023 Jun 16.
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History
Started
Dec 2025
Main results due
Dec 2026
Finished
Dec 2027