Rituximab
Used off label
Not approved for MS anywhere. Used off label for MS, most widely in Sweden and Norway, on the basis of trials such as HERMES, RIFUND-MS and OVERLORD-MS.
How it works: Removing B cells →
Riabni, Rituxan, Rituxan Hycela, Ruxience, Truxima, Zimrixby
- Molecule type
- Antibody
- Mechanism (ChEMBL)
- B-lymphocyte antigen CD20 binding agent
- Targets
- B-lymphocyte antigen CD20
Safety communications
- EMA safety letter (DHPC) · 17 August 2023
RoActemra / Hemlibra / Herceptin / Kadcyla / MabThera / Phesgo / Tecentriq: Quality defect Source
Most-reported side effects (FDA reports)
Reports to the FDA's adverse event system (FAERS) show what people and doctors reported while taking the medicine. They do not prove the medicine caused it, and they are not rates.
231,812 reports in total, 207,558 marked serious.
- Off label use46,908
- Drug ineffective37,162
- Rheumatoid arthritis22,083
- Pain19,208
- Fatigue18,742
- Arthralgia14,586
- Rash14,463
- Pneumonia14,135
- Infusion related reaction13,903
- Drug intolerance13,548
Trials
Key trials
Large trials with a reported result on their main goal.
- RItuximab Versus FUmarate in Newly Diagnosed Multiple Sclerosis.
Completed · Phase 3 · Relapsing MS · Met its main goal
- Comparison of Clinical Effects of Azathioprine and Rituximab NMO-SD Pa
Completed · Phase 2 / Phase 3 · NMOSD · Met its main goal
- A Study to Evaluate the Safety and Efficacy of Rituximab in Adults Wit
Completed · Phase 2 / Phase 3 · Progressive MS · Missed its main goal
Running now
- The HIt HArd and hiT Early in Multiple Sclerosis Trial
Recruiting · Phase 2 · Relapsing MS · Still running
- Rituximab Versus Ravulizumab, Inebilizumab, Satralizumab, and Eculizum
Recruiting · Phase 4 · NMOSD · Still running
- Immune System Effects in Children Born to Women With Multiple Sclerosi
Not yet recruiting · MS (type not specified) · Still running
- Immediate Versus Delayed Treatment With Azathioprine or Rituximab in A
Recruiting · Phase 3 · MOGAD · Still running
- The Effect of Rituximab on Cognitive and Hand Functions in Secondary P
Recruiting · Phase 2 · Progressive MS · Still running
- RItuximab Versus Ocrelizumab in Relapsing-remitting Multiple Sclerosis
Recruiting · Phase 3 · Relapsing and progressive · Still running
- Noisy Rebels; Non-inferiority study of rituximab compared to ocrelizum
Running, not recruiting · Phase 4 · Relapsing MS · Still running
- Non-inferiority Study of Rituximab Compared to Ocrelizumab in Relapsin
Recruiting · Phase 3 · Relapsing MS · Still running
- Non-inferiority Study of Ocrelizumab and Rituximab in Active Multiple
Running, not recruiting · Phase 3 · Relapsing and progressive · Still running
- Ocrelizumab VErsus Rituximab Off-Label at the Onset of Relapsing MS Di
Running, not recruiting · Phase 3 · Relapsing MS · Still running
Other trials (30)
Completed small trials, dose-finding studies and trials in other diseases.
- B-cell Depletion in Offspring to Women With MS Under Immunomodulatory
Status unknown · MS (type not specified) · No results found
- Inebilizumab and Rituximab in Neuromyelitis Optica Spectrum Disorders
Status unknown · NMOSD · No results found
- Safety and Efficacy of Intrathecal Rituximab in Patients With Multiple
Status unknown · Phase 1 · MS (type not specified) · No results found
- Safety and Efficacy of Cladribine Therapy After Anti CD20 Therapy
Status unknown · Relapsing MS · No results found
- Non-inferiority study of ocrelizumab and rituximab in active multiple
Moved to EU CTIS registry · Phase 3 · Progressive MS
- Ocrelizumab VErsus Rituximab off-Label at the Onset of Relapsing MS Di
Moved to EU CTIS registry · Phase 3 · Relapsing MS
- Autologous Transplant To End NMO Spectrum Disorder
Withdrawn · Phase 2 / Phase 3 · NMOSD · Stopped
- Norwegian Study of Oral Cladribine and Rituximab in Multiple Sclerosis
Completed · Phase 3 · Relapsing MS · No results found
- A Clinical Study Comparing Rituximab and Cladribine for Relapsing Mult
Completed · Phase 3 · Relapsing MS · No results found
- RItuximab Long-Term DOSE Trial in Multiple Sclerosis - RIDOSE-MS
Status unknown · Phase 3 · Relapsing MS · No results found
For information only, not medical advice. Talk to your neurologist before changing treatment.
Hypotheses involving this medicine
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Lab studies
Lab studies in animals or cells. Results in animals often do not hold in people, and these studies never change the status of an idea.
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