Randomised, Double-blind, Placebo-controlled, Parallel-group, Dose-ran
Randomised, Double-blind, Placebo-controlled, Parallel-group, Dose-ranging Study to Investigate the MRI Efficacy and the Safety of Six Months' Administration of Firategrast (150 – 1200mg twice daily) in Subjects with Relapsing-Remitting Multiple Sclerosis
What it found
The trial ended early for another reason (see below).
What was tested
Treatment tested
- Firategrast
Integrin alpha-4/beta-1 antagonist|Integrin alpha-4/beta-7 antagonist
What it measured
Main measures
The primary endpoint is the cumulative number of new gadolinium-enhancing lesions on monthly MRI scans. MRI is an accepted surrogate marker of MS burden of disease for exploratory trials.
MRI lesions
Who could take part
Relapsing MS
Show the full criteria
Inclusion criteria
Inclusion: 1. Written informed consent Exclusion: 1. Subjects receiving corticosteroids within 4 weeks of Screening for treatment of MS. If non-systemic steroids are being used for other chronic inflammatory conditions, subjects may be included at the discretion of the investigator after discussion with the GSK medical monitor
Exclusion criteria
Not separately supplied in the registry.
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
• To investigate the MRI efficacy of six months' administration of Firategrast in subjects with relapsing-remitting MS
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History
Started
Aug 2006