How Side Effects of Avonex Are Affected by Gradually Increasing to Ful
An Open-Label Study to Examine the Difference in Tolerability Associated With Titration Of Dose on Initiation of Avonex therapY (TODAY)
What it found
The trial ended early for another reason (see below).
Reason given: Terminated due to poor recruitment
This trial finished 18 years ago. We found no results in the registry or in any paper that cites it.
What was tested
Treatment tested
- Interferon beta-1a
Interferon alpha/beta receptor agonist
What it measured
Main measures
To assess the mean severity of episodes of FLS during the 4 week titration phase
4 weeks
Other measures (1)
To assess the mean severity and duration of FLS episodes in post-titration phase
throughout study
Who could take part
Relapsing MS · 18 and over
Show the full criteria
Inclusion criteria
* Diagnosis of clinically-definite relapsing-remitting multiple sclerosis
Exclusion criteria
* Any Product Information-specified contraindications to interferon-beta therapy, or other medical factors which, in the opinion of the investigator, make the subject unsuitable for interferon-beta therapy * Use of AVONEX, but not other interferon therapies, in the 3 months prior to randomisation into the study * A clinically significant infectious illness (e.g., cellulitis, abscess, pneumonia, septicemia) within 30 days prior to randomisation. * History of seizure in the 3 months prior to randomisation * History of suicidal ideation or severe depression within the 3 months prior to randomisation. * Other inclusion and exclusion criteria may apply per study protocol
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
This study is to find out if starting at low dose Avonex and slowly increasing to full dose will improve flu like symptoms as a side effect of Avonex treatment.
Loading reviews and guidelines…
Related trials
- Disease Modifying Therapies Withdrawal in Inactive Relapsing-remitting
Phase 3 · Not yet recruiting
Still running
- Pregnancy Exposure Registry for Vumerity (Diroximel Fumarate)
Recruiting
Still running
- Discontinuation of first-line disease modifying treatment (DMT) in lon
Phase 4 · Stopped early
Stopped
- A Study to Learn More About The Safety of Diroximel Fumarate (VUMERITY
Running, not recruiting
Still running
- Study to Investigate Pregnancy Outcomes in Female Participants Exposed
Completed
Paper found, not read
- A Study to Evaluate the Safety, Tolerability, and Efficacy of BIIB017
Phase 3 · Running, not recruiting
Still running
History
Started
Jun 2007
Main results due
Feb 2008
Finished
Feb 2008