CDP323 Biomarker Study
Double-blind, Placebo-controlled, Randomized, Parallel-group Study in Subjects With Relapsing Forms of Multiple Sclerosis to Evaluate the Effects of Different CDP323 Doses on Biomarker Patterns as Well as on Safety and Tolerability.
What it found
A paper reports the results; we have not read it yet. See Papers below.
What was tested
Treatment tested
- Ucb-1184197
Integrin alpha-4 inhibitor
Placebo
- Placebo
What it measured
Main measures
Pharmacodynamic parameters related to leukocyte trafficking
4 weeks
Other measures (2)
Standard and disease-related safety variables
4 weeks
SafetyClass-related safety parameters
4 weeks
Safety
Who could take part
Relapsing MS · 18 to 65 · EDSS 0 to 6.5
Show the full criteria
Inclusion criteria
* Female and male subjects aged 18-65 years * Relapsing form of MS with at least one clinical relapse in the 24 months before screening; * Screening EDSS score of 0-6.5; * Must be fully immunocompetent * Female subjects of childbearing potential must agree to practice contraception methods
Exclusion criteria
* Any conditions that could interfere with the contrast-enhanced MRI; * Any clinically significant disease state or findings other than MS; * Any clinically significant deviation from the pre-defined ranges for laboratory tests; * Concomitant treatment with MS disease modifying drugs
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
Comparison of the effects of different CDP323 doses given over a period of four weeks on blood biomarkers in subjects with relapsing forms of multiple sclerosis.
Papers
Loading reviews and guidelines…
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History
Started
Jul 2008
Main results due
Mar 2009
Finished
Mar 2009