Diroximel fumarate
How it works: Calming and slowing immune cells →
Vumerity
EU: Approved in the EU since 2021US: FDA approved 2019
- Molecule type
- Small molecule
- Mechanism (ChEMBL)
- Kelch-like ECH-associated protein 1 inhibitor
- Targets
- Kelch-like ECH-associated protein 1
- Availability
- Authorised in all EU and EEA countries. Reimbursement is decided by each country.
Approvals
Safety communications
None recorded.
Most-reported side effects (FDA reports)
Reports to the FDA's adverse event system (FAERS) show what people and doctors reported while taking the medicine. They do not prove the medicine caused it, and they are not rates.
12,103 reports in total, 4,667 marked serious.
- Flushing1,642
- Multiple sclerosis1,122
- Multiple sclerosis relapse998
- Diarrhoea884
- Product dose omission issue829
- Fatigue795
- Nausea760
- Headache635
- Pruritus603
- Memory impairment581
Trials
Key trials
Large trials with a reported result on their main goal.
- A Tolerability Study of ALKS 8700 in Subjects With Relapsing Remitting
Completed · Phase 3 · Relapsing MS · Met its main goal
Running now
- A Study to Learn About the Safety of Diroximel Fumarate (DRF) and Dime
Not yet recruiting · Phase 3 · Relapsing MS · Still running
- A Prospective Randomized Non-inferiority Trial Comparing Anti-CD20 Mai
Recruiting · Phase 3 · Relapsing and progressive · Still running
- Disease Modifying Therapies Withdrawal in Inactive Relapsing-remitting
Not yet recruiting · Phase 3 · Relapsing MS · Still running
- A Study to Evaluate Long-Term Safety of Vumerity and Tecfidera in Part
Running, not recruiting · MS (type not specified) · Still running
- Pregnancy Exposure Registry for Vumerity (Diroximel Fumarate)
Recruiting · Relapsing MS · Still running
- Prospective Evaluation of De-Escalation From antiCD-20 Therapies to Di
Running, not recruiting · Relapsing MS · Still running
- A Study to Learn More About The Safety of Diroximel Fumarate (VUMERITY
Running, not recruiting · Relapsing MS · Still running
Other trials (7)
Completed small trials, dose-finding studies and trials in other diseases.
- A Study to Learn About the Safety of BIIB091 and Its Effect on Brain I
Completed · Phase 2 · Relapsing and progressive · Paper found, not read
- Exploring Diroximel Fumarate Real-world Experience in Canada and Israe
Terminated · Relapsing and progressive · Stopped
- A Study of Diroximel Fumarate (DRF) in Adult Participants From the Asi
Completed · Phase 3 · Relapsing MS · Results posted, not judged
- Study of Diroximel Fumarate in the Real-World Setting
Terminated · Relapsing and progressive · Stopped
- Relationship Between Oral DMT Burden and Adherence in MS
Status unknown · MS (type not specified) · No results found
- A Study of ALKS 8700 in Adults With Relapsing Remitting Multiple Scler
Completed · Phase 3 · Relapsing MS · Results posted, not judged
- A Study of ALKS 8700, a Monomethyl Fumarate (MMF) Molecule, in Healthy
Completed · Phase 1 · MS (type not specified) · No results found
For information only, not medical advice. Talk to your neurologist before changing treatment.
Hypotheses involving this medicine
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Lab studies
Lab studies in animals or cells. Results in animals often do not hold in people, and these studies never change the status of an idea.
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