Laquinimod
How it works: Calming and slowing immune cells →
EU: RefusedUS: Not FDA approved
- Molecule type
- Small molecule
Approvals
- EU/EEANerventra · Refused19 August 2014 Source
Other regulatory events
- Refused · Nerventra19 August 2014 Source
Safety communications
None recorded.
Most-reported side effects (FDA reports)
Reports to the FDA's adverse event system (FAERS) show what people and doctors reported while taking the medicine. They do not prove the medicine caused it, and they are not rates.
13 reports in total, 10 marked serious.
- Psychiatric decompensation5
- Oral herpes2
- Affective disorder1
- Agranulocytosis1
- Altered state of consciousness1
- Back pain1
- C-reactive protein abnormal1
- Chest discomfort1
- Completed suicide1
- Condition aggravated1
Trials
Key trials
Large trials with a reported result on their main goal.
- The Efficacy, Safety, and Tolerability of Laquinimod in Participants W
Completed · Phase 3 · Relapsing MS · Missed its main goal
- BRAVO Study: Laquinimod Double-blind Placebo-controlled Study in Parti
Completed · Phase 3 · Relapsing MS · Missed its main goal
- Safety and Efficacy of Orally Administered Laquinimod Versus Placebo f
Completed · Phase 3 · Relapsing MS · Met its main goal
Other trials (7)
Completed small trials, dose-finding studies and trials in other diseases.
- A Phase 2 Clinical Study in Subjects With Primary Progressive Multiple
Completed · Phase 2 · Progressive MS · Missed its main goal
- A Study to Evaluate 2 Doses Of Oral Administration Of Laquinimod Compa
Withdrawn · Phase 3 · Relapsing MS · Stopped
- A Study to Evaluate the Long-term Safety, Tolerability and Effect of D
Terminated · Phase 3 · Relapsing MS · Stopped
- A Study To Evaluate the Long-Term Safety, Tolerability and Effect on D
Terminated · Phase 3 · Relapsing MS · Stopped
- Study Title: A multinational, multicenter, randomized, double-blind,
Terminated · Phase 3 · Relapsing MS · Stopped
- An Extension Study of LAQ/5062 Exploring the Long Term Safety, Tolerab
Terminated · Phase 2 · Relapsing MS · Stopped
- A Study to Evaluate the Effectiveness, Tolerability and Safety of Laqu
Completed · Phase 2 · Relapsing MS · Paper found, not read
For information only, not medical advice. Talk to your neurologist before changing treatment.
Hypotheses involving this medicine
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Lab studies
Lab studies in animals or cells. Results in animals often do not hold in people, and these studies never change the status of an idea.
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